Adherence of packing defects in soluble proteins -: art. no. 018102
Adherence of packing defects in soluble proteins -: art. no. 018102
复制标题
DOI：
10.1103/physrevlett.91.018102
复制
发表时间：
2003-07-04
影响因子：
8.6
通讯作者：
Scott, LR
中科院分区：
文献类型：
--
作者：
Fernández, A;Scott, LR
为了使蛋白质结构在水中占主导地位，它的骨架氢键必须受到水的攻击，这需要一簇“包裹”非极性基团。因此，由于外部去除周围的水变得有利，因此未被包裹的区域是粘性的。在这里，我们测量的平均粘附力施加的一个underwrapped的氢键上的测试疏水，从而定义一个新的相互作用常数。
For protein structure to prevail in water, its backbone hydrogen bonds must be shielded from water attack, requiring a cluster of "wrapping" nonpolar groups. Thus, underwrapped regions are adhesive, as exogenous removal of surrounding water becomes thermodynamically favorable. Here we measure the average adhesive force exerted by an underwrapped hydrogen bond on a test hydrophobe and thus define a new interactivity constant.