Hormonal Modulation of Pheromone Detection Enhances Male Courtship Success.
Hormonal Modulation of Pheromone Detection Enhances Male Courtship Success.
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DOI：
10.1016/j.neuron.2016.05.004
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发表时间：
2016-06-15
期刊：
影响因子：
16.2
通讯作者：
Wang JW
中科院分区：
文献类型：
--
作者：
Lin HH;Cao DS;Sethi S;Zeng Z;Chin JSR;Chakraborty TS;Shepherd AK;Nguyen CA;Yew JY;Su CY;Wang JW
在大多数动物的一生中，生殖成熟和交配活动是高度协调的。例如，在黑腹果蝇中，雄性生育力随着年龄的增长而增加，并且已知年长的雄性比年轻的雄性具有交配优势。这种与年龄相关的交配行为差异的分子和神经基础尚不清楚。在这里，我们表明，Or47b气味受体所需的交配优势的老年男性。值得注意的是，Or47b神经元对刺激性信息素棕榈油酸的敏感性在年轻男性中较低，但在老年男性中较高，这解释了老年男性更高的求爱强度。从机制上讲，这种与年龄相关的Or47b神经元敏化需要生殖激素、保幼激素以及Or47b神经元中的甲氧普仑耐受性结合蛋白。总之，我们的研究确定了保幼激素的直接神经基质，允许求爱活动与生殖成熟的协调，以最大限度地提高男性生殖健康。
During the lifespans of most animals, reproductive maturity and mating activity are highly coordinated. In Drosophila melanogaster, for instance, male fertility increases with age and older males are known to have a copulation advantage over young ones. The molecular and neural basis of this age-related disparity in mating behavior is unknown. Here we show that the Or47b odorant receptor is required for the copulation advantage of older males. Notably, the sensitivity of Or47b neurons to a stimulatory pheromone, palmitoleic acid, is low in young males but high in older ones, which accounts for older males’ higher courtship intensity. Mechanistically, this age-related sensitization of Or47b neurons requires a reproductive hormone, juvenile hormone, as well as its binding protein Methoprene-tolerant in Or47b neurons. Together, our study identifies a direct neural substrate for juvenile hormone that permits coordination of courtship activity with reproductive maturity to maximize male reproductive fitness.