Mild debenzylation of aryl benzyl ether with BCl3 in the presence of pentamethylbenzene as a non-Lewis-basic cation scavenger
Mild debenzylation of aryl benzyl ether with BCl3 in the presence of pentamethylbenzene as a non-Lewis-basic cation scavenger
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DOI：
10.1055/s-2008-1077980
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发表时间：
2008-08-01
期刊：
影响因子：
2
通讯作者：
Tokuyama, Hidetoshi
中科院分区：
文献类型：
--
作者：
Okano, Kentaro;Okuyama, Kei-ichiro;Tokuyama, Hidetoshi
本文研究了在矢田霉素合成研究中开发的芳基苄醚脱苄条件的适用范围和局限性。在低温条件下，以BCl（3）和五甲基苯为阳离子清除剂，在不同官能团存在下进行化学选择性脱苄基反应。
Scope and limitations of the debenzylation conditions for aryl benzyl ether, which was developed during our synthetic studies on yatakemycin, were investigated. The chemoselective debenzylation proceeds at low temperature with a combination of BCl(3) and pentamethylbenzene as a cation scavenger in the presence of various functional groups.