An integrative view on sex differences in brain tumors.
An integrative view on sex differences in brain tumors.
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DOI：
10.1007/s00018-015-1930-2
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Rubin JB
中科院分区：
文献类型：
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作者：
Sun T;Plutynski A;Ward S;Rubin JB
人类健康和疾病的性别差异可以从无法察觉到深刻。脑肿瘤发病率和结果的差异在全世界的男性和女性中是明显的，无论年龄如何。这些观察结果表明，性别决定的基本方面可以影响脑肿瘤的生物学。治疗男性和女性脑肿瘤患者的最佳个性化方法可能需要认识和理解肿瘤生物学的差异。我们认为，通过严格记录男性和女性脑肿瘤发病率和结局的差异，并了解性别差异的发育和进化起源，将加强针对性别的脑肿瘤筛查和护理方法。在这里，我们提供了这样一个综合的角度对脑肿瘤。我们的目的是鼓励在临床和基础科学研究中考虑性别差异。
Sex differences in human health and disease can range from undetectable to profound. Differences in brain tumor rates and outcome are evident in males and females throughout the world and regardless of age. These observations indicate that fundamental aspects of sex determination can impact the biology of brain tumors. It is likely that optimal personalized approaches to the treatment of male and female brain tumor patients will require recognizing and understanding the ways in which the biology of their tumors can differ. It is our view that sex-specific approaches to brain tumor screening and care will be enhanced by rigorously documenting differences in brain tumor rates and outcomes in males and females, and understanding the developmental and evolutionary origins of sex differences. Here we offer such an integrative perspective on brain tumors. It is our intent to encourage the consideration of sex differences in clinical and basic scientific investigations.