Association between maternal smoking and increased symptom severity in Tourette's syndrome.
Association between maternal smoking and increased symptom severity in Tourette's syndrome.
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母亲吸烟与抽动秽语综合征症状严重程度增加之间的关联。
DOI：
10.1176/ajp.2006.163.6.1066
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Reus,VictorI
中科院分区：
文献类型：
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作者：
Mathews,CarolA;Bimson,Brianne;Lowe,ThomasL;Herrera,LuisDiego;Budman,CathyL;Erenberg,Gerald;Naarden,Allen;Bruun,RuthD;Freimer,NelsonB;Reus,VictorI
大量证据表明，环境和遗传因素都有助于Tourette综合征的发展和临床表现。虽然抽动秽语综合征的遗传学研究很常见，但环境因素的研究相对较少，并且没有在研究中确定一致的风险因素。本研究在一个大的受试者队列（N=180）中检查产前/围产期不良事件与图雷特综合征严重程度之间的关系，图雷特综合征严重程度由抽动严重程度和常见共病障碍如强迫症（OCD）、注意缺陷多动障碍（ADHD）和自伤行为的比率确定。在三项抽动秽语综合征遗传学研究中，对所有受试者进行系统评估，并暴露于各种产前/围产期事件。使用线性和Logistic回归，最佳拟合模型确定为每个结果的interests.ResultsPrenatal母亲吸烟与抽搐的严重程度增加，并与这些抽动秽语综合征患者的共病强迫症的存在密切相关。其他变量，如父亲的年龄和受试者的出生体重，显着，但不太强烈的症状严重程度增加。作者发现症状严重程度和缺氧，产钳分娩，或妊娠期间的剧吐，这已被确定为危险因素之间没有关联。ConclusionsThis study identifies prednisonic maternal smoking as a strong risk factor for increased symptoms severity in Tourette's syndrome.
ObjectiveSubstantial evidence suggests that both environmental and genetic factors contribute to the development and clinical expression of Tourette’s syndrome. Although genetic studies of Tourette’s syndrome are common, studies of environmental factors are relatively few and have not identified consistent risk factors across studies. This study examines in a large cohort of subjects (N=180) the relationship between prenatal/perinatal adverse events with Tourette’s syndrome severity as determined by tic severity and rates of commonly comorbid disorders such as obsessive-compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), and self-injurious behavior.MethodTic severity, OCD, ADHD, self-injurious behavior, and exposure to a variety of prenatal/perinatal events were systematically assessed in all subjects enrolled in three genetic studies of Tourette’s syndrome. Using linear and logistic regression, a best-fit model was determined for each outcome of interest.ResultsPrenatal maternal smoking was strongly correlated with increased tic severity and with the presence of comorbid OCD in these Tourette’s syndrome subjects. Other variables, such as paternal age and subject’s birth weight, were significantly but less strongly associated with increased symptom severity. The authors found no association between symptom severity and hypoxia, forceps delivery, or hyperemesis during pregnancy, which have been previously identified as risk factors.ConclusionsThis study identifies prenatal maternal smoking as a strong risk factor for increased symptom severity in Tourette’s syndrome.