Systemic immunity and mucosal immunity are induced against human immunodeficiency virus Gag protein in mice by a new hyperattenuated strain of Listeria monocytogenes.
Systemic immunity and mucosal immunity are induced against human immunodeficiency virus Gag protein in mice by a new hyperattenuated strain of Listeria monocytogenes.
复制标题
一种新的超减毒单核细胞增生李斯特菌菌株在小鼠体内诱导针对人类免疫缺陷病毒 Gag 蛋白的全身免疫和粘膜免疫。
DOI：
10.1128/jvi.75.6.2786-2791.2001
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发表时间：
2001
影响因子：
5.4
通讯作者：
Frankel,FR
中科院分区：
文献类型：
--
作者：
Rayevskaya,MV;Frankel,FR
Vaccines designed to control chronic infections by intracellular agents such as human immunodeficiency virus type 1 (HIV-1) require the induction of cell-mediated immune responses to rid the host of pathogen-infected cells.Listeria monocytogeneshas characteristics that make it an attractive vaccine vector for use against such infections. Here we show that parenteral immunization with a new highly attenuated strain of this organism provided complete protection against systemic and mucosal challenges with a recombinant vaccinia virus expressing HIV-1gag. Immunization also generated a strong, long-term memory cytotoxic-T-lymphocyte (CTL) response in spleen, mesenteric lymph nodes, and Peyer's patches directed against thegagprotein. Oral immunization with this attenuated strain also produced complete, long-lasting protection against the recombinant virus but only against mucosal virus challenge. Curiously, oral immunization was associated with a transient CTL response in the three lymphoid tissues examined.
