miR-71b regulation of insulin/IGF-1 signaling during starvation in planarians.
miR-71b regulation of insulin/IGF-1 signaling during starvation in planarians.
复制标题
涡虫饥饿期间 miR-71b 对胰岛素/IGF-1 信号传导的调节。
DOI：
10.4238/2015.october.5.4
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Shusheng Zhang
中科院分区：
文献类型：
--
作者：
Yangjie Wu;J. M. Zhao;Q. Liu;Q. Guo;Zhangsuo Liu;X. X. Wang;C. Y. Wang;R. Li;Yin Zhang;Shusheng Zhang
涡虫拥有大量称为新生细胞的干细胞，是用于再生研究的分子可处理模型系统。然而，涡虫对饥饿有很强的抵抗力，并制定了生长抑制策略。例如，它们可以在饥饿期间改变体型并经历生长衰退。目前的研究结果表明，microRNA、miR-71b和胰岛素/IGF-1信号通路在饥饿诱导的涡虫的发育中具有重要功能。我们使用原位杂交证明了 miR-71b 的组织特异性表达。通过采用实时聚合酶链反应，我们提供了 miR-71b 在饥饿诱导的涡虫中上调的证据。此外，我们验证并验证了miR-71b的靶基因。
Planarians, which have a large population of stem cells called neoblasts, are molecularly tractable model systems used in the study of regeneration. However, planarians have strong resistance to hunger and have developed growth arrest strategies. For example, they can change their size and undergo growth regression during starvation periods. The results of the current study show that the microRNA, miR-71b, and the insulin/IGF-1 signaling pathway have important functions in the development of starvation-induced planarians. We demonstrate tissue-specific expression of miR-71b using in situ hybridization. By employing real-time polymerase chain reaction, we provide evidence that miR-71b is upregulated in starvation-induced planarians. Furthermore, we validate and verify the target genes of miR-71b.
影响因子：
0.7
作者：
Gonzalez-Estevez, Cristina;Felix, Daniel A.;Aboobaker, A. Aziz
通讯作者：
Aboobaker, A. Aziz