Fabrication and magnetic control of alginate-based rolling microrobots
Fabrication and magnetic control of alginate-based rolling microrobots
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DOI：
10.1063/1.4971277
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发表时间：
2016-12-01
期刊：
影响因子：
1.6
通讯作者：
Kim, Min Jun
中科院分区：
文献类型：
--
作者：
Ali, Jamel;Cheang, U. Kei;Kim, Min Jun
用于生物应用的微型机器人的进展往往受到限制，因为它们的复杂制造工艺通常使用细胞毒性材料，以及无线操作这些小型设备的能力的限制。为了克服这些挑战，我们研究了一种简便的方法来制造生物兼容的水凝胶机器人，这些机器人能够使用外部产生的磁场进行操纵。在这里，我们实验演示了负载海藻酸盐微球的制造和自主控制，我们称之为人工细胞。为了产生这些微粒，我们采用了一种基于离心机的方法，在这种方法中，微球从喷嘴尖端快速喷射出来。具体地说，我们使用了两种海藻酸钠混合物；一种含有氧化铁纳米颗粒，另一种含有哺乳动物细胞。将这种混合物装入固定在含有氯化钙的微管顶部的针中，然后短暂离心，生成数百个Janus微球。然后，利用电磁线圈产生的旋转磁场对制造出来的微粒进行磁力驱动，促使微粒在玻璃基板上滚动。此外，使用基于视觉的反馈控制，单个人造细胞被操纵以按编程模式自主移动。(C)2016年作者(S)。
Advances in microrobotics for biological applications are often limited due to their complex manufacturing processes, which often utilize cytotoxic materials, as well as limitations in the ability to manipulate these small devices wirelessly. In an effort to overcome these challenges, we investigated a facile method for generating biocompatible hydrogel based robots that are capable of being manipulated using an externally generated magnetic field. Here, we experimentally demonstrate the fabrication and autonomous control of loaded-alginate microspheres, which we term artificial cells. In order to generate these microparticles, we employed a centrifuge-based method in which microspheres were rapidly ejected from a nozzle tip. Specifically, we used two mixtures of sodium alginate; one containing iron oxide nanoparticles and the other containing mammalian cells. This mixture was loaded into a needle that was fixed on top of a microtube containing calcium chloride, and then briefly centrifuged to generate hundreds of Janus microspheres. The fabricated microparticles were then magnetically actuated with a rotating magnetic field, generated using electromagnetic coils, prompting the particles to roll across a glass substrate. Also, using vision-based feedback control, a single artificial cell was manipulated to autonomously move in a programmed pattern. (C) 2016 Author(s).