Rhodium-catalyzed asymmetric hydroarylation of diphenylphosphinylallenes with arylboronic acids
Rhodium-catalyzed asymmetric hydroarylation of diphenylphosphinylallenes with arylboronic acids
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DOI：
10.1021/ja058763f
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发表时间：
2006-03-01
影响因子：
15
通讯作者：
Hayashi, T
中科院分区：
文献类型：
--
作者：
Nishimura, T;Hirabayashi, S;Hayashi, T
铑催化的二苯基膦基联烯与芳基硼酸的不对称氢芳基化反应高产率、高区域选择性和高对映选择性地合成了手性烯丙基氧化膦，其ee值高达98%，关键中间体π-烯丙基铑配合物的结构测定成功地建立了该反应的催化循环。
Rhodium-catalyzed asymmetric hydroarylation of diphenylphosphinylallenes with arylboronic acids proceeded in high yields with high regio- and enantioselectivity to give chiral allylphosphine oxides of up to 98% ee. The structural determination of the key intermediate, a π-allylrhodium complex, was successful to establish the catalytic cycle of the reaction.