Mass-forming extramedullary hematopoiesis diagnosed by fine-needle aspiration cytology
Mass-forming extramedullary hematopoiesis diagnosed by fine-needle aspiration cytology
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DOI：
10.1002/dc.20557
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发表时间：
2006-12-01
影响因子：
1.3
通讯作者：
Atkins, Kristen A.
中科院分区：
文献类型：
--
作者：
Policarpio-Nicolas, Maria Luisa C.;Bregman, Shelli G.;Atkins, Kristen A.
髓外造血（EMH）通常是显微镜下发现。然而，它可能表现为肿块形成的病变，使其适合细针穿刺活检（FNAB）。当肿块形成EMH发生时，它可以在临床和放射学上模拟肿瘤。此外，巨核细胞可以模仿恶性肿瘤细胞，特别是如果EMH不是一个考虑的诊断。我们报告六例肿块形成EMH诊断细针穿刺活检和评估的效用，细针穿刺活检诊断EMH。4例患者既往诊断为血液系统疾病，1例患者患有恶性肥大细胞增多症，表现为淋巴结病，1例患者有癌症病史。患者年龄46 ~ 78岁，性别分布均匀。抽吸涂片显示三系造血。细胞形态学鉴别诊断包括转移癌、霍奇金淋巴瘤和髓样肉瘤。由于经典的细胞学结果和既往血液学病史，无需特殊染色。
Extramedullary hematopoiesis (EMH) is usually a microscopic finding. However, it may present as a mass-forming lesion making it amenable to fine-needle aspiration biopsy (FNAB) When mass-forming EMH occurs, it can simulate a neoplasm clinically and radiologically. Additionally, the megakaryocytes can mimic malignant neoplastic cells, particularly if EMH is not a considered diagnosis. We report six cases of mass-forming EMH diagnosed by FNAB and evaluate the utility of FNAB in diagnosing EMH. Four patients had prior diagnoses of hematologic disorders, one patient had malignant mastocytosis who presented with lymphadenopathy and one patient had a history of carcinoma. The patients' ages ranged from 46 to 78 yr with an equal sex distribution. Aspirate smears showed trilineage hematopoiesis. The cytomorphologic differential diagnosis included metastatic carcinoma, Hodgkin lymphoma and myeloid sarcoma. No special stains were necessary due to the classic cytologic findings and prior hematologic history.