The Nuclear Pore Complex Is a Key Target of Viral Proteases to Promote Viral Replication.
The Nuclear Pore Complex Is a Key Target of Viral Proteases to Promote Viral Replication.
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DOI：
10.3390/v13040706
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发表时间：
2021-04-19
期刊：
影响因子：
--
通讯作者：
Del Ángel RM
中科院分区：
文献类型：
--
作者：
De Jesús-González LA;Palacios-Rápalo S;Reyes-Ruiz JM;Osuna-Ramos JF;Cordero-Rivera CD;Farfan-Morales CN;Gutiérrez-Escolano AL;Del Ángel RM
各种病毒通过改变核孔复合体（NPC）的完整性来获取有利于其复制的核内容物。核孔复合物的改变不仅在细胞核内复制的病毒中被观察到，而且在具有细胞质复制周期的病毒中也被观察到。在最后一种情况下，NPC的改变可以减少参与免疫反应或mRNA成熟的转录因子的运输，或抑制mRNA从细胞核到细胞质的运输，有利于病毒mRNA的翻译或允许进入病毒复制所需的核因子。在大多数情况下，鼻咽癌的改变是由病毒蛋白介导的，即病毒蛋白酶，它是调节这些核-胞质转运变化的最关键的病毒蛋白群之一。本文就病毒蛋白酶在修饰病毒细胞质复制周期的核-胞质转运过程中的作用及其对病毒复制的影响作一综述。
Various viruses alter nuclear pore complex (NPC) integrity to access the nuclear content favoring their replication. Alteration of the nuclear pore complex has been observed not only in viruses that replicate in the nucleus but also in viruses with a cytoplasmic replicative cycle. In this last case, the alteration of the NPC can reduce the transport of transcription factors involved in the immune response or mRNA maturation, or inhibit the transport of mRNA from the nucleus to the cytoplasm, favoring the translation of viral mRNAs or allowing access to nuclear factors necessary for viral replication. In most cases, the alteration of the NPC is mediated by viral proteins, being the viral proteases, one of the most critical groups of viral proteins that regulate these nucleus–cytoplasmic transport changes. This review focuses on the description and discussion of the role of viral proteases in the modification of nucleus–cytoplasmic transport in viruses with cytoplasmic replicative cycles and its repercussions in viral replication.
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影响因子：
4.8
作者：
Brooks, AJ;Johansson, M;Vasudevan, SG
通讯作者：
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作者：
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DOI：
10.1016/j.biocel.2006.07.006
发表时间：
2007
期刊：
The international journal of biochemistry & cell biology
影响因子：
--
作者：
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通讯作者：
Leatherbarrow RJ
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作者：
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通讯作者：
del Angel, RM