Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry
Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry
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DOI：
10.1016/j.neuroimage.2005.09.029
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发表时间：
2006-04-01
期刊：
影响因子：
5.7
通讯作者：
Drevets, WC
中科院分区：
文献类型：
--
作者：
Nugent, AC;Milham, MP;Drevets, WC
双相情感障碍（BD）与脑结构异常有关。具体而言，BID的体内体积MRI和/或死后研究报告了内侧前额叶皮质（PFC）、杏仁核、海马下托和腹侧纹状体中的灰质（GM）体积异常。这些结构彼此共享解剖学连接，并形成调节情绪行为的“内脏”网络的一部分。眶外侧、上级颞叶和后扣带回皮质投射到该网络，但BD中这些区域的形态测量异常尚未确定。目前的研究使用MRI和基于体素的形态测量法（VBM）评估了这些区域内的组织体积。为了说明精神药物可能的神经营养和神经保护作用，将BID受试者分为给药组和未给药组。图像被分割成组织室，这是一个voxel-wise的基础上进行检查，以确定位置和程度的形态学changes. GM减少后扣带/压后皮质和上级颞回的未用药BD受试者相对于用药BD受试者和在侧眶皮质的用药BD受试者相对于对照组。白色物质（WM）增加，在眼眶和后扣带回皮质，这最有可能反映在相关GM的减少所造成的脑回形态的变化。在后扣带回，上级颞叶和外侧眶皮质BD的形态测量异常支持的假设，即扩展网络的神经解剖结构subserving内脏调节包含结构变化BID。此外，形态测量异常的区域，已知表现出增加代谢抑郁症支持的假设，反复的压力和糖皮质激素分泌升高可能会导致神经可塑性的变化，在BD。(c)2005年爱思唯尔公司All rights reserved.
Bipolar disorder (BD) has been associated with abnormalities of brain structure. Specifically, in vivo volumetric MRI and/or post mortern studies of BID have reported abnormalities of gray matter (GM) volume in the medial prefrontal cortex (PFC), amygdala, hippocampal subiculum and ventral striatum. These structures share anatomical connections with each other and form part of a "visceromotor" network modulating emotional behavior. Areas of the lateral orbital, superior temporal and posterior cingulate cortices project to this network, but morphometric abnormalities in these areas have not been established in BD. The current study assessed tissue volumes within these areas in 131) using MRI and voxel-based morphometry (VBM).MRI images were obtained from 36 BD subjects and 65 healthy controls. To account for possible neurotrophic and neuroprotective effects of psychotropic medications, BID subjects were divided into medicated and unmedicated groups. Images were segmented into tissue compartments, which were examined on a voxel-wise basis to determine the location and extent of morphometric changes.The GM was reduced in the posterior cingulate/retrosplenial cortex and superior temporal gyrus of unmedicated BD subjects relative to medicated BD subjects and in the lateral orbital cortex of medicated BD subjects relative to controls. White matter (WM) was increased in the orbital and posterior cingulate cortices, which most likely reflected alterations in gyral morphology resulting from the reductions in the associated GM.The morphometric abnormalities in the posterior cingulate, superior temporal and lateral orbital cortices in BD support the hypothesis that the extended network of neuroanatomical structures subserving visceromotor regulation contains structural alterations in BID. Additionally, localization of morphometric abnormalities to areas known to exhibit increased metabolism in depression supports the hypothesis that repeated stress and elevated glucocorticoid secretion may result in neuroplastic changes in BD. (c) 2005 Elsevier Inc. All rights reserved.