Enhancing Both Biodegradability and Efficacy of Semiconducting Polymer Nanoparticles for Photoacoustic Imaging and Photothermal Therapy
Enhancing Both Biodegradability and Efficacy of Semiconducting Polymer Nanoparticles for Photoacoustic Imaging and Photothermal Therapy
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增强用于光声成像和光热治疗的半导体聚合物纳米粒子的生物降解性和功效
DOI：
10.1021/acsnano.7b08616
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发表时间：
2018-02-01
期刊：
影响因子：
17.1
通讯作者：
Pu, Kanyi
中科院分区：
文献类型：
--
作者：
Lyu, Yan;Zeng, Jianfeng;Pu, Kanyi
治疗性纳米药物在精准医疗方面很有前景。然而，具有光声（PA）成像引导光热治疗（PTT）能力的可生物降解纳米剂是罕见的。我们在此报道了生物可降解的半导体聚合物纳米颗粒（SPNs）的发展，其具有增强的PA和PTT治疗癌症的功效。该设计利用了乙烯键的酶氧化特性，结合聚合物化学，合成了一种可生物降解的半导体聚合物（DPPV），并将其转化为水溶性纳米颗粒（SPNV）。与相对应的SPN （SPNT）相比，聚合物骨架内乙烯键的存在也使SPNV的质量吸收系数（1.3倍）和光热转换效率（2.4倍）显著提高。因此，SPNV提供了比SPNT更高的PA信号和光热最高温度，使活鼠肿瘤的检测和光热消融更加灵敏和有效。因此，我们的研究揭示了一种通用的分子设计，可以增强光学活性聚合物纳米颗粒的生物降解性，同时显著提高其成像和治疗能力。
Theranostic nanoagents are promising for precision medicine. However, biodegradable nanoagents with the ability for photoacoustic (PA) imaging guided photothermal therapy (PTT) are rare. We herein report the development of biodegradable semiconducting polymer nanoparticles (SPNs) with enhanced PA and PTT efficacy for cancer therapy. The design capitalizes on the enzymatically oxidizable nature of vinylene bonds in conjunction with polymer chemistry to synthesize a biodegradable semiconducting polymer (DPPV) and transform it into water-soluble nanoparticles (SPNV). As compared with its counterpart SPN (SPNT), the presence of vinylene bonds within the polymer backbone also endows SPNV with a significantly enhanced mass absorption coefficient (1.3-fold) and photothermal conversion efficacy (2.4-fold). As such, SPNV provides the PA signals and the photothermal maximum temperature higher than SPNT, allowing detection and photothermal ablation of tumors in living mice in a more sensitive and effective way. Our study thus reveals a general molecular design to enhance the biodegradability of optically active polymer nanoparticles while dramatically elevating their imaging and therapeutic capabilities.