Transplacental Transfer of Per- and Polyfluoroalkyl Substances (PFASs): Differences between Preterm and Full-Term Deliveries and Associations with Placental Transporter mRNA Expression
Transplacental Transfer of Per- and Polyfluoroalkyl Substances (PFASs): Differences between Preterm and Full-Term Deliveries and Associations with Placental Transporter mRNA Expression
复制标题
全氟烷基物质和多氟烷基物质 (PFAS) 的经胎盘转移：早产和足月分娩之间的差异以及与胎盘转运蛋白 mRNA 表达的关联
DOI：
10.1021/acs.est.0c00829
复制
发表时间：
2020-04-21
影响因子：
11.4
通讯作者：
Chen, Da
中科院分区：
文献类型：
--
作者：
Li, Jing;Cai, Dan;Chen, Da
先前的研究表明，全氟烷基物质和多氟烷基物质（PFAS）可以穿过人类胎盘屏障。然而，它们的经胎盘转运效率（TTE）尚未在早产中进行研究，并且胎盘转运蛋白的作用也很少被探索。我们的研究假设早产和足月分娩时 PFAS 的 TTE 可能不同，并且一些胎盘转运蛋白可能参与母胎 PFAS 的主动转移。在本研究中，早产儿 (N = 86) 匹配的母体脐带血清对中 16 种 PFAS 化学物质或异构体的中位 TTE 确定为 0.23 至 1.72，显着低于足月分娩 (N = 187) 中确定的 TTE 中值 (0.35 至 2.26)。确定了几种 PFAS 的 TTE 与刷状缘膜上选定转运蛋白的 mRNA 表达水平之间存在显着相关性。早产和足月分娩之间的关联模式也存在显着差异，并且表现出化学特异性的方式。例如，在足月分娩中，MRP2 的表达与直链和支链全氟辛烷磺酸 (PFOS) 异构体的 TTE 表现出显着的正相关，但在早产中却观察到负的、不显着的相关。这是第一项比较早产和足月分娩之间 PFAS 经胎盘转移的研究，并表明一些胎盘转运蛋白可能参与主动传播。 PFAS 跨胎盘转移的机制需要进一步研究，以更好地阐明其对胎儿健康和出生结果的风险。
Previous studies demonstrated that per- and polyfluoroalkyl substances (PFASs) can cross the human placental barrier. However, their transplacental transfer efficiencies (TTEs) have not been investigated in preterm delivery, and the role of placental transport proteins has rarely been explored. Our study hypothesized that the TTEs of PFASs could differ between preterm and full-term deliveries, and some placental transporters could be involved in active maternofetal PFAS transfer. In the present study, the median TTEs of 16 individual PFAS chemicals or isomers were determined to be 0.23 to 1.72 in matched maternal-cord serum pairs with preterm delivery (N = 86), which were significantly lower than those (0.35 to 2.26) determined in full-term delivery (N = 187). Significant associations were determined between the TTEs of several PFASs and the mRNA expression levels of selected transporters located on the brush border membrane. The association patterns also significantly differed between preterm and full-term deliveries and exhibited a chemical-specific manner. For example, the expression of MRP2 exhibited significantly positive associations with the TTEs of linear and branched perfluorooctanesulfonic acid (PFOS) isomers in full-term delivery, but negative, nonsignificant associations were observed in preterm delivery. This is the first study to compare the transplacental transfer of PFASs between preterm and full-term deliveries and indicate that some placental transport proteins could be involved in active transmission. The mechanisms underlying the cross-placental transfer of PFASs require further investigations to better elucidate their risks to fetal health and birth outcomes.