Stochastic Food Deprivation Increases Cellular Immunity in Kunming Mice
Stochastic Food Deprivation Increases Cellular Immunity in Kunming Mice
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DOI：
10.4236/health.2014.611136
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发表时间：
2014-05
期刊：
影响因子：
2.1
通讯作者：
De-Li Xu;Yufen Tian;Ruisheng Li;Haotian Li;Xiaonan Sun;Qingbin Wang;Jing Shi;P. Zhou;Xiaolei Sun
中科院分区：
文献类型：
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作者：
De-Li Xu;Yufen Tian;Ruisheng Li;Haotian Li;Xiaonan Sun;Qingbin Wang;Jing Shi;P. Zhou;Xiaolei Sun
动物的免疫力是决定其生存和健康的重要因素。由于一年中食物资源的波动，小型哺乳动物普遍存在不可预测的食物短缺。一般来说，急性食物剥夺(FD)会抑制啮齿动物的免疫功能。在目前的研究中，我们验证了随机FD也会抑制小鼠T细胞介导的免疫的假设。成年雄性昆明种小鼠15只，随机分为FED组(n=7)和FD组(n=8)。出乎意料的是，与喂饲对照组相比，用PHA反应评估的T细胞介导的免疫反应在FD小鼠中增加。然而，FED组和FD组之间的体脂质量、湿胸腺和脾质量、白细胞、血清瘦素和皮质酮浓度没有差异。综上所述，随机食物剥夺可增强昆明种小鼠的细胞免疫功能。
Animals’ immunity is an important factor to determine their survival and fitness. Unpredictable food shortage is common to small mammals due to fluctuation of food resources throughout a year. In general, acute food deprivation (FD) inhibited immune function in rodents. In the present study we tested the hypothesis that stochastic FD would also suppress T cell-mediated immunity in mice. Fifteen adult male Kunming mice were randomly assigned into the Fed (n = 7) and FD (n = 8) groups, in which the latter were subjected to stochastic FD regime. Unexpectedly, T cell-mediated immunity assessed by PHA response was increased in the FD mice compared with the fed controls. However, body fat mass, wet thymus and spleen mass, white blood cells, serum leptin and corticosterone concentrations did not differ between the Fed and FD groups. Taken together, stochastic food deprivation can enhance cellular immunity in Kunming mice.