DYNAMICS OF MITRAL REGURGITANT FLOW AND ORIFICE AREA - PHYSIOLOGICAL APPLICATION OF THE PROXIMAL FLOW CONVERGENCE METHOD - CLINICAL-DATA AND EXPERIMENTAL TESTING
DYNAMICS OF MITRAL REGURGITANT FLOW AND ORIFICE AREA - PHYSIOLOGICAL APPLICATION OF THE PROXIMAL FLOW CONVERGENCE METHOD - CLINICAL-DATA AND EXPERIMENTAL TESTING
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DOI：
10.1161/01.cir.90.1.307
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发表时间：
1994-07-01
期刊：
影响因子：
37.8
通讯作者：
LEVINE, RA
中科院分区：
文献类型：
--
作者：
SCHWAMMENTHAL, E;CHEN, CG;LEVINE, RA
背景：近端血流会聚法是一种定量彩色多普勒血流技术，最近已被证实可用于计算返流和瓣口面积。我们调查了潜在的方法作为一种工具，以研究不同的病理生理机制的二尖瓣关闭不全，通过评估的时间过程中的反流和孔口面积，并分析了量化的二尖瓣返流的影响。方法和结果五十六连续不同病因的二尖瓣返流患者进行了研究。根据近端血流会聚区的彩色M模式记录计算瞬时返流流速Q（（t）），并除以相应的瓣口速度V-（t），以获得瞬时瓣口面积A（（t））。通过积分Q（（t））获得瑞格列汀每搏输出量（RSV）。通过RSV除以返流时间计算平均返流流速Qm（）。计算峰均流速Q（p）/Q（m）和瓣口面积A（p）/A（m），以评价Q（t）和P-（t）的相位特征。前24例患者（组1），将彩色多普勒记录的Q（m）和RSV计算与常规脉冲多普勒方法进行比较（r= 0.94，SEE=29.4 mL/s和r= 0.95，SEE=9.7 mL）以及血管造影（r（s）= 0.93和r（s）= 0.94，P
Background The proximal how convergence method, a quantitative color Doppler flow technique, has been validated recently for calculating regurgitant flow and orifice area. We investigated the potential of the method as a tool to study different pathophysiological mechanisms of mitral valve incompetence by assessing the time course of regurgitant flow and orifice area and analyzed the implications for quantification of mitral regurgitation.Methods and Results Fifty-six consecutive patients with mitral regurgitation of different etiologies were studied. The instantaneous regurgitant flow rate Q((t)) was computed from color M-mode recordings of the proximal flow convergence region and divided by the corresponding orifice velocity V-(t) to obtain the instantaneous orifice area A((t)). Regurgitant stroke volume (RSV) was obtained by integrating Q((t)). Mean regurgitant flow rate Qm( )was calculated by RSV divided by regurgitation time. Peak-to-mean regurgitant flow rates Q(p)/Q(m) and orifice areas A(p)/A(m) were calculated to assess the phasic character of Q((t)) and P-(t) In the first 24 patients (group 1), computation of Q(m) and RSV from the color Doppler recordings was compared with the conventional pulsed Doppler method (r=.94, SEE=29.4 mL/s and r=.95, SEE=9.7 mL) as well as with angiography (r(s)=.93 and r(s)=.94, P