The response of human platelets to activated components of the complement system.
The response of human platelets to activated components of the complement system.
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DOI：
10.1016/0167-5699(91)90012-i
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发表时间：
1991-09
期刊：
影响因子：
--
通讯作者：
Peter J. Sims;T. Wiedmer
中科院分区：
文献类型：
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作者：
Peter J. Sims;T. Wiedmer
许多体内血小板应答被认为是由补体系统的活化组分直接或间接介导的。这些包括蛋白水解酶的分泌以及凝血和纤溶途径的关键酶的组装。在这篇综述中，Peter J.西姆斯和Therese Wiedmer总结了已知的人类血小板与补体系统的相互作用，并讨论了这些相互作用对血管系统内血小板止血功能的影响。这些效应中的一些似乎是由免疫球蛋白直接介导的，或者需要血小板与补体系统组分的特异性相互作用，而另一些是通过血小板与免疫刺激的白细胞释放的炎症介质的相互作用介导的。这篇综述专门关注血小板与一种或多种活化补体蛋白直接相互作用的反应。将评估活化补体成分对血小板止血功能的影响，以及补体激活的血小板活化在各种凝血病中的作用。
Many in vivo platelet responses are considered to be mediated, directly or indirectly, by activated components of the complement system. These include the secretion of proteolytic enzymes and the assembly of key enzymes of the coagulation and fibrinolytic pathways. In this review, Peter J. Sims and Therese Wiedmer summarize the known interactions of human platelets with the complement system and discuss the implications of these interactions for platelet hemostatic function within the vasculature.It has been recognized for many years that immunological reactions can profoundly alter platelet function and survival within the vasculature 1-s. Some of these effects appear to be mediated directly by immunoglobulin or entail specific interaction of platelets with components of the complement system, while others are mediated through the interaction of platelets with inflammatory mediators released by immune-stimulated leukocytes. This review focuses exclusively on the response of platelets to direct interaction with one or more activated complement proteins. The effects of activated complement components on platelet hemostatic function will be assessed, as will the contribution of complementevoked platelet activation in various coagulopathies.