ANTIDEPRESSANT AND CIRCADIAN PHASE-SHIFTING EFFECTS OF LIGHT
ANTIDEPRESSANT AND CIRCADIAN PHASE-SHIFTING EFFECTS OF LIGHT
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DOI：
10.1126/science.3798117
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发表时间：
1987-01-16
期刊：
影响因子：
56.9
通讯作者：
HOBAN, TM
中科院分区：
文献类型：
--
作者：
LEWY, AJ;SACK, RL;HOBAN, TM
明亮的光线可以抑制人体夜间褪黑激素的产生，但普通的室内光线没有这种效果。这一发现表明，强光也可能对人类产生其他的时间生物学影响。8名经常在冬季（白天变短）出现抑郁症状的患者，在早晨接触强光1周后（但在晚上接触强光1周后没有好转），症状明显改善。对晨光的抗抑郁反应伴随着夜间褪黑激素产生的提前（转移到更早的时间）。这些结果表明，对强光的抗抑郁作用来说，时间可能至关重要。
Bright light can suppress nighttime melatonin production in humans, but ordinary indoor light does not have this effect. This finding suggested that bright light may have other chronobiologic effects in humans as well. Eight patients who regularly became depressed in the winter (as day length shortens) significantly improved after 1 week of exposure to bright light in the morning (but not after 1 week of bright light in the evening). The antidepressant response to morning light was accompanied by an advance (shift to an earlier time) in the onset of nighttime melatonin production. These results suggest that timing may be critical for the antidepressant effects of bright light.