Further studies on platelet serotonin transporter binding in depression.
Further studies on platelet serotonin transporter binding in depression.
复制标题
抑郁症中血小板血清素转运蛋白结合的进一步研究。
DOI：
--
复制
发表时间：
1994
影响因子：
17.7
通讯作者：
K. Krishnan
中科院分区：
文献类型：
--
作者：
Charles B. Nemeroff;D. Knight;J. Franks;W. E. Craighead;K. Krishnan
目的
有一个令人印象深刻的文献暗示抑郁症中的多巴胺能神经系统异常。许多研究者，但不是所有的，已经报道了在无药物的抑郁症患者中血小板和脑5-羟色胺（5-HT）转运位点的数量较少。在本研究中，作者试图确定抑郁症患者血小板5-HT转运蛋白结合率低是否是由于既往抗抑郁药物暴露所致。此外，[3 H]丙咪嗪和更具体的配体[3 H]帕罗西汀与血小板5-HT转运蛋白的结合在无药物的抑郁症患者和年龄和性别匹配的正常对照受试者中进行了比较。
方法
第一个实验从12名从未接受过抗抑郁药物治疗的抑郁症患者和12名正常对照者中采集血样，用[3 H]丙咪嗪测定血小板5-HT转运体结合。在第二个实验中，从28名无药物的抑郁症患者和28名年龄和性别匹配的对照组中获得血液样本，并使用[3 H]丙咪嗪和[3 H]帕罗西汀评估血小板5-HT转运体结合。
结果
在第一个实验中，从未服药的抑郁症患者表现出较少的血小板[3 H]丙咪嗪结合位点比对照组。在第二个实验中，与对照组相比，无药物的抑郁症患者对[3 H]丙咪嗪和[3 H]帕罗西汀的血小板结合位点较少。
结论
血小板[3 H]丙咪嗪结合位点数量较少似乎不是由于既往抗抑郁药物暴露所致。[3 H]丙咪嗪和[3 H]帕罗西汀（用于测量5-HT转运体结合的配体）的血小板结合位点的Bmax在抑郁症患者中异常低。
OBJECTIVE
There is an impressive literature implicating abnormalities in serotonergic neural systems in depression. Many investigators, but not all, have reported low numbers of platelet and brain serotonin (5-HT) transporter sites in drug-free depressed patients. In the present study the authors sought to determine whether the low platelet 5-HT transporter binding in depressed patients is due to previous antidepressant drug exposure. In addition, the binding of both [3H]imipramine and the more specific ligand [3H]paroxetine to the platelet 5-HT transporter was compared in drug-free depressed patients and age- and sex-matched normal comparison subjects.
METHOD
In the first experiment blood samples were obtained from 12 depressed patients who had never received antidepressant drugs and 12 normal comparison subjects, and platelet 5-HT transporter binding was measured by using [3H]imipramine. In the second experiment blood samples were obtained from 28 drug-free depressed patients and 28 age- and sex-matched comparison subjects, and platelet 5-HT transporter binding was assessed by using both [3H]imipramine and [3H]paroxetine.
RESULTS
In the first experiment the never-medicated depressed patients exhibited fewer platelet [3H]imipramine binding sites than did the comparison subjects. In the second experiment the drug-free depressed patients had fewer platelet binding sites for both [3H]imipramine and [3H]paroxetine than did the comparison subjects.
CONCLUSIONS
The low number of platelet [3H]imipramine binding sites does not appear to be due to prior antidepressant drug exposure. The Bmax of platelet binding sites for both [3H]imipramine and [3H]paroxetine, ligands used to measure 5-HT transporter binding, is abnormally low in depressed patients.
抑郁症中血清素能神经元系统的神经化学改变。
DOI：
--
发表时间：
1992
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Risch,SC;Nemeroff,CB
通讯作者：
Nemeroff,CB