Autophagy and cancer metabolism.
Autophagy and cancer metabolism.
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DOI：
10.1016/b978-0-12-416618-9.00002-9
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发表时间：
2014
影响因子：
--
通讯作者：
Debnath J
中科院分区：
文献类型：
--
作者：
Goldsmith J;Levine B;Debnath J
为了在不利的微环境条件下维持其生存和增殖，恶性细胞的代谢发生了深刻的改变。自噬是一种细胞内循环过程，可在饥饿或其他形式的应激下维持代谢物和生物合成中间体的基础水平，因此是癌细胞代谢适应的重要机制。尽管人们普遍认为自噬在胁迫下维持肿瘤细胞的新陈代谢，但关于癌症中自噬和代谢之间的相互关系仍然存在许多问题。重要的是，自噬通常被描述为一把“双刃剑”，它可以阻止或促进癌症的发生和进展。在这里，我们概述了自噬在肿瘤发生中的双重功能，以及我们目前对自噬和癌细胞代谢在控制肿瘤生长、进展和治疗抵抗中的协调调节的理解。
The metabolism of malignant cells is profoundly altered in order to maintain their survival and proliferation in adverse microenvironmental conditions. Autophagy is an intracellular recycling process that maintains basal levels of metabolites and biosynthetic intermediates under starvation or other forms of stress, hence serving as an important mechanism for metabolic adaptation in cancer cells. Although it is widely acknowledged that autophagy sustains metabolism in neoplastic cells under duress, many questions remain with regard to the mutual relationship between autophagy and metabolism in cancer. Importantly, autophagy has often been described as a “double-edged sword” that can either impede or promote cancer initiation and progression. Here, we overview such a dual function of autophagy in tumorigenesis and our current understanding of the coordinated regulation of autophagy and cancer cell metabolism in the control of tumor growth, progression, and resistance to therapy.