Internalising symptoms mediate the longitudinal association between childhood inflammation and psychotic-like experiences in adulthood
Internalising symptoms mediate the longitudinal association between childhood inflammation and psychotic-like experiences in adulthood
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DOI：
10.1016/j.schres.2019.07.035
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发表时间：
2020-01-01
影响因子：
4.5
通讯作者：
Flouri, Eirini
中科院分区：
文献类型：
--
作者：
Francesconi, Marta;Minichino, Amedeo;Flouri, Eirini
精神病样经历（PLEs）是精神病连续体的一部分。以前的纵向研究强调了儿童期外周炎症与成年期PLEs发作之间的关系。在这项研究中，我们测试了这种关联是否由儿童和青少年时期经历的内化和外化症状介导。为了验证这一假设，我们使用了雅芳父母和孩子纵向研究（ALSPAC）的数据。我们调查了来自该队列的4525名个体的子样本，其中包括儿童（9岁）白细胞介素6（IL-6）和C反应蛋白（CRP）的数据。我们在18岁时测量了PLEs，并使用潜在生长曲线模型来估计9至16岁的内化和外化症状的纵向轨迹。然后在中介分析中使用截距（设定为基线，9年）和斜率（年变化率）的个体预测值。有证据表明，通过拦截内化症状进行了完全调解。我们的研究结果表明，儿童时期的炎症可能与未来发生的PLEs有关，通过其与高水平的内化症状的相关性。这些发现，虽然从非临床人群中获得，但为推进炎症与精神病症状之间关系的知识提供了额外的一步。(C)2019 Elsevier B. V.版权所有。
Psychotic-like experiences (PLEs) are part of a continuum of psychosis. Previous longitudinal studies highlighted a relationship between peripheral inflammation during childhood and onset of PLEs in adulthood. In this study, we tested if this association is mediated by internalising and externalising symptoms experienced during childhood and adolescence. To test this hypothesis, we used data from the Avon Longitudinal Study of Parents and Children (ALSPAC). We investigated a subsample of 4525 individuals from this cohort with data on interleukin 6 (IL-6) and C-reactive protein (CRP) in childhood (age 9 years). We measured PLEs at age 18 years, and we used latent growth curve modelling to estimate longitudinal trajectories of internalising and externalising symptoms from ages 9 to 16 years. The individual predicted values of the intercept (set at baseline, 9 years) and the slope (rate of annual change) were then used in the mediation analysis. There was evidence for full mediation by the intercept of internalising symptoms. Our findings suggest that inflammation during childhood may be relevant for the future onset of PLEs via its association with a high level of internalising symptoms. These findings, although obtained from a non-clinical population, provide an additional step in advancing knowledge on the relationship between inflammation and symptoms of the psychosis continuum. (C) 2019 Elsevier B.V. All rights reserved.