The inherited basis of human radiosensitivity
The inherited basis of human radiosensitivity
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DOI：
10.1080/02841860152619115
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发表时间：
2001-01-01
期刊：
影响因子：
3.1
通讯作者：
Gatti, RA
中科院分区：
文献类型：
--
作者：
Gatti, RA
某些人不能忍受“常规”剂量的放射治疗。这在共济失调-毛细血管扩张症和连接酶IV缺乏症患者中是正确的。虽然体外试验可能与患者的临床放射敏感性、成纤维细胞和淋巴母细胞并不完全相关，但这两种疾病都已被清楚地证明是放射敏感性的。使用集落存活试验(CSA)检测1Gy射线照射后的淋巴母细胞样细胞，已发现多种其他遗传性疾病被认为是临床放射敏感性的有力候选者。如奈梅根破裂综合征、MREL-1缺乏症和范可尼氏贫血。这些数据被认为是人类辐射敏感性遗传基础的起点。
Certain individuals cannot tolerate 'conventional' doses of radiation therapy. This is known to be true of patients with ataxia-telangiectasia and ligase IV deficiency. Although in vitro testing may not correlate completely with clinical radiosensitivity, fibroblasts and lymphoblasts from patients,vith both of these disorders have been clearly shown to be radiosensitive. Using a colony survival assay (CSA) to test lymphoblastoid cells after irradiation with 1 Gy, a variety of other genetic disorders have been identified as strong candidates for clinical radiosensitivity. such as Nijmegen breakage syndrome, Mrel 1 deficiency, and Fanconi's anemia. These data are presented and considered as a starting-point for the inherited basis of human radiosensitivity.