Serum Sodium Levels and Patient Outcomes in an Ambulatory Clinic-Based Chronic Kidney Disease Cohort
Serum Sodium Levels and Patient Outcomes in an Ambulatory Clinic-Based Chronic Kidney Disease Cohort
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DOI：
10.1159/000381193
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发表时间：
2015-01-01
影响因子：
4.2
通讯作者：
Saran, Rajiv
中科院分区：
文献类型：
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作者：
Han, Sang-Woong;Tilea, Anca;Saran, Rajiv
背景：慢性肾脏病（CKD）患者易发生低钠血症和高钠血症。关于非透析CKD非卧床患者低钠血症和高钠血症的流行病学研究很少。研究方法：合并并分析了两项同期CKD队列研究（肾脏研究所（RRI）-CKD研究（n = 834）和肾功能不全治疗研究：数据和评价（STRIDE）（n = 1，348））中收集的数据，以研究血清钠（Na+）与临床结局之间的相关性。结果：基线估计肾小球滤过率（eGFR）和Na+分别为26 +/- 11 ml/min/1.73 m（2）和140.2 +/- 3.4 mEq/l。Na+ = 144 mEq/l的患病率分别为6%和16%。较高的基线Na+与男性、年龄较大、收缩压、BMI、血清白蛋白、心力衰竭和较低的eGFR显著相关。Na+患者发生终末期肾病（ESRD）的风险略高，
Background: Chronic kidney disease (CKD) patients are prone to both hypo- and hypernatremia. Little has been published on the epidemiology of hypo- and hypernatremia in ambulatory patients with non-dialysis CKD. Methods: Data collected in two contemporaneous CKD cohort studies, the Renal Research Institute (RRI)-CKD study (n = 834) and the Study of Treatment of Renal Insufficiency: Data and Evaluation (STRIDE) (n = 1,348) were combined and analyzed to study the association between serum sodium (Na+) and clinical outcomes. Results: Baseline estimated glomerular filtration rate (eGFR) and Na+ were 26 +/- 11 ml/min/1.73 m(2) and 140.2 +/- 3.4 mEq/l, respectively. The prevalence of Na+ = 144 mEq/l was 6 and 16%, respectively. Higher baseline Na+ was significantly associated with male sex, older age, systolic blood pressure, BMI, serum albumin, presence of heart failure, and lower eGFR. The risk of end-stage renal disease (ESRD) was marginally significantly higher among patients with Na+