Genetic and environmental determinants of peak bone mass in young men and women
Genetic and environmental determinants of peak bone mass in young men and women
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DOI：
10.1359/jbmr.2002.17.7.1273
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发表时间：
2002-07-01
影响因子：
6.2
通讯作者：
Ralston, SH
中科院分区：
文献类型：
--
作者：
McGuigan, FEA;Murray, L;Ralston, SH
峰值骨量是晚年骨质疏松症发展的重要危险因素。以前的研究表明，遗传、子宫内和环境因素都有助于调节骨量，但它们相互作用的方式仍然知之甚少。在这项研究中，我们调查了峰值骨量和维生素D受体（VDR），雌激素受体（ER）α和I型胶原蛋白1（COLIA1）基因多态性与其他因素（如出生体重，生活方式饮食和运动）之间的关系，在20岁出头的216名女性和244名男性的人群队列中。逐步多元回归分析显示，体重是女性骨密度（BMD）的最强预测因子，占脊柱BMD方差的16.4%，占股骨颈BMD方差的8.4%。其他重要的预测因子是脊柱的VDR基因型（3.8%）和碳水化合物摄入量（1.6%）以及股骨颈的维生素D摄入量（3.4%）和ER基因型（3.4%）。体力活动是男性BMD的最强预测因子，占脊柱变异的6.7%和髋部变异的5.1%。其他重要的预测因素是体重（5%）和ER PvuII基因型（2.8%）在脊柱和体重（3.4%）和酒精摄入量（2%）在股骨颈。出生体重不是BMD的显著预测因子，但COLIA1基因型可显著预测女性的出生体重，占方差的4.3%。我们的结论是，峰值骨量是由一个重叠的，但不同的一套环境和遗传的影响，在男性和女性不同的调节。然而，BMD的大部分变化是无法解释的变量在这里研究，这表明，要么大多数的基因，调节BMD仍有待发现或主要的环境影响BMD存在尚未确定。
Peak bone mass is an important risk factor for the development of osteoporosis in later life. Previous work has suggested that genetic, intrauterine, and environmental factors all contribute to the regulation of bone mass, but the ways in which they interact with each other to do so remain poorly understood. In this study, we investigated the relationship between peak bone mass and polymorphisms of the vitamin D receptor (VDR), estrogen receptor (ER) alpha, and collagen type Ialpha1 (COLIA1) genes in relation to other factors such as birth weight, lifestyle diet, and exercise in a population-based cohort of 216 women and 244 men in their early 20s. Stepwise multiple regression analysis showed that body weight was the strongest predictor of bone mineral density (BMD) in women, accounting for 16.4% of the variance in spine BMD and 8.4% of the variance in femoral neck BMD. Other significant predictors were VDR genotype (3.8%) and carbohydrate intake (1.6%) at the spine and vitamin D intake (3.4%) and ER genotype (3.4%) at the femoral neck. Physical activity was the strongest predictor of BMD in men, accounting for 6.7% of the variance at the spine and 5.1% at the hip. Other significant predictors were body weight (5%) and ER PvuII genotype (2.8%) at the spine and weight (3.4%) and alcohol intake (2%) at the femoral neck. Birth weight was not a significant predictor of BMD at either site but COLIA1 genotype significantly predicted birth weight in women, accounting for 4.3% of the variance. We conclude that peak bone mass is regulated by an overlapping but distinct set of environmental and genetic influences that differ in men and women. However, much of the variance in BMD was unexplained by the variables studied here, which suggests that either most of the genes that regulate BMD remain to be discovered or major environmental influences on BMD exist that have not yet been identified.