ENERGY-EXPENDITURE AND WASTING IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION
ENERGY-EXPENDITURE AND WASTING IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION
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DOI：
10.1056/nejm199507133330202
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发表时间：
1995-07-13
影响因子：
158.5
通讯作者：
GRIFFIN, GE
中科院分区：
文献类型：
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作者：
MACALLAN, DC;NOBLE, C;GRIFFIN, GE
背景。休息时能量消耗增加被认为是人类免疫缺陷病毒（HIV）感染患者出现能量负平衡和体重减轻的一个因素。然而，能量平衡的真正决定因素不是休息，而是总能量消耗。我们试图确定总能量消耗对艾滋病毒相关消瘦患者体重变化的影响。方法。我们对 27 名 HIV 感染者在疾病的不同阶段（包括快速和缓慢体重减轻时期）进行了 51 次能量代谢评估。静息能量消耗通过间接量热法测量，总能量消耗通过双标记水技术测量，能量摄入通过记录消耗食物的重量来测量。将结果与体重减轻或增加的速率进行比较。 结果。 HIV感染者的平均（+/-SD）总能量消耗为每天2750+/-670 kcal，不超过正常男性的消耗量。总能量消耗与体重变化率呈显着正相关（r=0.61，P
Background. Increased expenditure of energy at rest has been considered a contributing factor to the negative energy balance and weight loss that occur in patients with human immunodeficiency virus (HIV) infection. However, the true determinant of energy balance is not resting but total energy expenditure. We sought to determine the contribution of total energy expenditure to weight changes in patients with HIV-associated wasting.Methods. We performed 51 assessments of energy metabolism in 27 men with HIV infection at different stages of disease, including periods of both rapid and slow weight loss. Resting energy expenditure was measured by indirect calorimetry, total energy expenditure by the doubly-labeled-water technique, and energy intake by recording the weight of food consumed. The results were compared with the rate of weight loss or gain.Results. The mean (+/-SD) total energy expended by the HIV-infected men was 2750+/-670 kcal per day, no more than that expended by normal men. There was a significant positive relation between total energy expenditure and the rate of weight change (r=0.61, P