TOXICOKINETICS OF OCHRATOXIN-A IN SEVERAL SPECIES AND ITS PLASMA-BINDING PROPERTIES
TOXICOKINETICS OF OCHRATOXIN-A IN SEVERAL SPECIES AND ITS PLASMA-BINDING PROPERTIES
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DOI：
10.1002/jat.2550090204
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发表时间：
1989-04-01
影响因子：
3.3
通讯作者：
FUCHS, R
中科院分区：
文献类型：
--
作者：
HAGELBERG, S;HULT, K;FUCHS, R
研究了口服或静脉注射50 ng/g体重的赭曲霉毒素A后的毒代动力学特征。对鱼、鹌鹑、老鼠、老鼠和猴子来说。消除半衰期从口服给药后0.68小时到静脉给药后840小时不等。在鱼类体内的分布体积为57ml/kg，在鹌鹑体内的分布体积为1500ml/kg。其中，鹌鹑和鱼类的血浆清除速度最快，分别为72和58 mg/kg。H，而只有0.17 mg/kg.cntdot。在猴子身上。在鱼体内的生物利用度低至1.6%，在小鼠体内的生物利用度高达97%。此外，还研究了赭曲霉毒素A与血浆蛋白的结合能力。根据这些数据，我们计算了血浆中毒素的游离部分，我们发现除了鱼之外，所有被调查的物种(包括人)中的毒素含量为0.2%。此外，还进行了类似但规模较小的研究，研究了赭曲霉毒素B的毒代动力学和结合特性。赭曲霉毒素B更容易被消除，与血浆蛋白的亲和力较低，这可能是其毒性较低的部分原因。
The toxicokinetic profile of ochratoxin A was studied after the oral or intervenous administration of 50 ng/g b.w. to fish, quail, mouse, rat and monkey. The elimination half-life varied from 0.68 hr after oral administration to fish, up to 840 h after intravenous administration to monkey. The distribution volume ranged from 57 ml/kg in fish to 1500 ml/kg in quail. The plasma clearance was most rapid in quail and fish, 72 and 58 mg/kg .cntdot. h, respectively, while it was only 0.17 mg/kg .cntdot. h in monkey. The bioavailability was as low as 1.6% in fish but as high as 97% in mouse. The binding abilities of ochratoxin A to plasma proteins were also studied. From these data we calculated the free fraction of toxin in plasma, which we found to be < 0.2% in all species investigated (including man) except fish. A similar but smaller investigation on the toxicokinetics and binding properties of ochratoxin B was also performed. Ochratoxin B was more readily eliminated and had a lower affinity for plasma proteins, which partly may explain its lower toxicity.