Quantative MRI predicts tendon mechanical behavior, collagen composition, and organization.
Quantative MRI predicts tendon mechanical behavior, collagen composition, and organization.
复制标题
定量 MRI 可预测肌腱的机械行为、胶原蛋白成分和组织。
DOI：
10.1002/jor.25471
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Zheng,Jie
中科院分区：
文献类型：
--
作者：
Zellers,JenniferA;Edalati,Masoud;Eekhoff,JeremyD;McNish,Reika;Tang,SimonY;Lake,SpencerP;Mueller,MichaelJ;Hastings,MaryK;Zheng,Jie
定量磁共振成像（qMRI）测量提供了对肌肉骨骼组织组成、质量和结构-功能的深入了解。低信噪比限制了对肌腱的应用。扫描序列和样本定位的进步改善了肌腱的信号，从而可以评估结构和功能。本研究旨在阐明肌腱qMRI指标（T1、T2、T1ρ和扩散张量成像[DTI]指标）与肌腱组织力学、胶原蛋白浓度和组织之间的关系。收集了16个人跟腱标本，用qMRI成像，并用定量偏振光成像进行机械测试。T2值与肌腱力学相关[峰值应力（rsp= 0.51，p = 0.044）、平衡应力（rsp= 0.54，p = 0.033）、松弛百分比（rsp= − 0.55，p = 0.027）、滞后（rsp= − 0.64，p = 0.007）、线性模量（rsp= 0.67，p = 0.009）]。T1ρ与舒张百分比有显著相关性（r= 0.50，p = 0.048）。胶原含量与DTI测量值显著相关（r = 0.56-0.62）。人类跟腱中部的单个切片的T2值是肌腱拉伸力学指标的最强预测因子。DTI扩散系数指数（平均扩散系数，轴向扩散系数，径向扩散系数）与胶原含量密切相关。这些发现建立在越来越多的文献基础上，这些文献支持qMRI表征肌腱组织和无创测量肌腱结构和功能的可行性。临床意义声明：定量MRI可用于表征肌腱组织，是一种与肌腱成分和力学行为相关的非侵入性测量方法。
Quantitative magnetic resonance imaging (qMRI) measures have provided insights into the composition, quality, and structure‐function of musculoskeletal tissues. Low signal‐to‐noise ratio has limited application to tendon. Advances in scanning sequences and sample positioning have improved signal from tendon allowing for evaluation of structure and function. The purpose of this study was to elucidate relationships between tendon qMRI metrics (T1, T2, T1ρ and diffusion tensor imaging [DTI] metrics) with tendon tissue mechanics, collagen concentration and organization. Sixteen human Achilles tendon specimens were collected, imaged with qMRI, and subjected to mechanical testing with quantitative polarized light imaging. T2 values were related to tendon mechanics [peak stress (rsp= 0.51,p= 0.044), equilibrium stress (rsp= 0.54,p= 0.033), percent relaxation (rsp= −0.55,p= 0.027), hysteresis (rsp= −0.64,p= 0.007), linear modulus (rsp= 0.67,p= 0.009)]. T1ρ had a statistically significant relationship with percent relaxation (r= 0.50,p= 0.048). Collagen content was significantly related to DTI measures (range ofr= 0.56–0.62). T2 values from a single slice of the midportion of human Achilles tendons were strongest predictors of tendon tensile mechanical metrics. DTI diffusivity indices (mean diffusivity, axial diffusivity, radial diffusivity) were strongly correlated with collagen content. These findings build on a growing body of literature supporting the feasibility of qMRI to characterize tendon tissue and noninvasively measure tendon structure and function. Statement of Clinical Significance: Quantitative MRI can be applied to characterize tendon tissue and is a noninvasive measure that relates to tendon composition and mechanical behavior.