Do different branching epithelia use a conserved developmental mechanism?
Do different branching epithelia use a conserved developmental mechanism?
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DOI：
10.1002/bies.10161
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发表时间：
2002-10-01
期刊：
影响因子：
4
通讯作者：
Davies, JA
中科院分区：
文献类型：
--
作者：
Davies, JA
由无分支的前体细胞形成分支的上皮树是动物器官发生中的常见过程。例如，在人类中，这一过程产生肺的气道、肾的集尿管以及乳腺、前列腺和唾液腺的排泄上皮。在这些不同的器官中，以及在不同的动物纲和门中，分支在形态上足够相似，表明它们可能使用保守的发育程序，同时又足够不同，不能明显确定它们确实如此。在这篇文章中，我回顾了最近发现的分子调控的分支形态发生在最好的研究系统，并提出证据支持和反对的想法，有一个高度保守的机制。总的来说，我得出的初步结论是，关键机制是高度保守的，至少在脊椎动物中是如此，但我承认，在排除合理怀疑之前，还需要做更多的工作。
Formation of branching epithelial trees from unbranched precursors is a common process in animal organogenesis. In humans, for example, this process gives rise to the airways of the lungs, the urine-collecting ducts of the kidneys and the excretory epithelia of the mammary, prostate and salivary glands. Branching in these different organs, and in different animal classes and phyla, is morphologically similar enough to suggest that they might use a conserved developmental programme, while being dissimilar enough not to make it obviously certain that they do. In this article, I review recent discoveries about the molecular regulation of branching morphogenesis in the best-studied systems, and present evidence for and against the idea of there being a highly conserved mechanism. Overall, I come to the tentative conclusion that key mechanisms are highly conserved, at least within vertebrates, but acknowledge that more work needs to be done before the case is proved beyond reasonable doubt.