Associations of 24-Hour Light Exposure and Activity Patterns and Risk of Cognitive Impairment and Decline in Older Men: The MrOS Sleep Study.
Associations of 24-Hour Light Exposure and Activity Patterns and Risk of Cognitive Impairment and Decline in Older Men: The MrOS Sleep Study.
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24 小时光照和活动模式与老年男性认知障碍和衰退风险的关联：MrOS 睡眠研究。
DOI：
10.1093/gerona/glac187
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
OsteoporoticFracturesinMen(MrOS)StudyGroup
中科院分区：
文献类型：
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作者：
Blackwell,TerriL;Figueiro,MarianaG;Tranah,GregoryJ;Zeitzer,JamieM;Yaffe,Kristine;Ancoli-Israel,Sonia;Kado,DeborahM;Ensrud,KristineE;Lane,NancyE;Leng,Yue;Stone,KatieL;OsteoporoticFracturesinMen(MrOS)StudyGroup
背景活动和光线协调性较差的老年男性可能认知水平较低，并且认知衰退率较高。方法该队列由来自 MrOS 睡眠研究（2009-2012）的 1036 名老年男性（81.1±4.6 岁）组成。通过手腕体动记录仪收集光线和活动水平。相量分析用于量化明暗和休息活动模式（幅度）的对齐及其时间关系（角度）。测量整体认知功能（改良简易精神状态检查 [3MS]）和执行功能（Trails B 测试），并在 4.2 ± 0.8 年后重复测量。线性回归模型检查了相量幅度和角度与认知和认知衰退的关联。根据年龄、临床、种族、教育和季节对模型进行调整。结果较小的相量幅度（较差的光和活动模式）与较低的初始水平和执行功能下降的加剧相关。与相量幅度较高的人相比，幅度较低的人完成 Trails B 测试的时间平均长 11.1 秒（四分位数 1 与四分位数 4，p= .02）。随访后，相量幅度每减少一个标准差，轨迹 B 的完成时间平均增加 5.5 秒（95% 置信区间 [CI] 0.7–10.4，p= .03）。与相量角度没有关联，与幅度和整体认知 (3MS) 也没有关联。结论在老年男性中，光线和活动模式的对齐较差与较差的初始表现和执行功能下降加剧相关，但与整体认知无关。改善光线和活动协调的干预措施可能会减缓老年人的认知能力下降。
BackgroundOlder men with the worse alignment of activity and light may have lower levels of cognition and increased rates of cognitive decline.MethodsThis cohort consisted of 1 036 older men (81.1 ± 4.6 years) from the MrOS Sleep Study (2009–2012). Light and activity levels were gathered by wrist actigraphy. Phasor analysis was used to quantify the alignment of light–dark and rest-activity patterns (magnitude) and their temporal relationship (angle). Global cognitive function (Modified Mini-Mental State examination [3MS]) and executive function (Trails B test) were measured, then repeated 4.2 ± 0.8 years later. Linear regression models examined the associations of phasor magnitude and angle with cognition and cognitive decline. Models were adjusted for age, clinic, race, education, and season.ResultsSmaller phasor magnitude (worse aligned light and activity patterns) was associated with lower initial level and increased decline in executive function. Compared to those with higher phasor magnitude, those with lower magnitude took an average of 11.1 seconds longer to complete the Trails B test (quartile 1 vs quartile 4,p= .02). After follow-up, Trails B completion time increased an average of 5.5 seconds per standard deviation decrease in phasor magnitude (95% confidence interval [CI] 0.7–10.4,p= .03). There were no associations with phasor angle, and none with magnitude and global cognition (3MS).ConclusionAmong older men, worse alignment of light and activity patterns was associated with worse initial performance and increased decline in executive function, but not related to global cognition. Interventions that improve the alignment of light and activity may slow cognitive decline in older adults.