Patterned silk films cast from ionic liquid solubilized fibroin as scaffolds for cell growth
Patterned silk films cast from ionic liquid solubilized fibroin as scaffolds for cell growth
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DOI：
10.1021/la062047p
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发表时间：
2007-01-30
期刊：
影响因子：
3.9
通讯作者：
Naik, Rajesh R.
中科院分区：
文献类型：
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作者：
Gupta, Maneesh K.;Khokhar, Shama K.;Naik, Rajesh R.
丝绸由于其缓慢的降解速度、优异的机械性能以及生物相容性，是一种用于组织工程应用的有吸引力的生物材料。在本报告中，我们展示了一种从溶解在离子液体中的丝素蛋白直接浇铸有图案薄膜的简单方法。发现由丝绸离子液体溶液浇铸的薄膜能够支持正常的细胞增殖和分化。丝绸离子液体溶液的多功能性以及能够直接从溶解的丝绸离子液体溶液中将大量丝绸加工成具有可控表面形貌的材料，这可以提高丝绸等生物材料在多种应用中的适用性。
Silk is an attractive biomaterial for use in tissue engineering applications because of its slow degradation, excellent mechanical properties, and biocompatibility. In this report, we demonstrate a simple method to cast patterned films directly from silk fibroin dissolved in an ionic liquid. The films cast from the silk ionic liquid solution were found to support normal cell proliferation and differentiation. The versatility of the silk ionic liquid solutions and the ability to process large amounts of silk into materials with controlled surface topography directly from the dissolved silk ionic liquid solution could enhance the desirability of biomaterials such as silk for a variety of applications.