Small Fiber Polyneuropathy in Hunner Lesion and Non-Hunner Lesion Interstitial Cystitis/Bladder Pain Syndrome
Small Fiber Polyneuropathy in Hunner Lesion and Non-Hunner Lesion Interstitial Cystitis/Bladder Pain Syndrome
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DOI：
10.1097/spv.0000000000000824
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发表时间：
2021-01-01
影响因子：
1.6
通讯作者：
Peters, Kenneth M.
中科院分区：
文献类型：
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作者：
Han, Esther;Killinger, Kim A.;Peters, Kenneth M.
本研究旨在确定Hunner病变间质性膀胱炎/膀胱疼痛综合征（HL IC/BPS）和非Hunner病变IC/BPS（NHL IC/BPS）之间小纤维多发性神经病（SVPN）的诊断是否不同。方法对20例女性IC/BPS患者进行初步研究。收集基线问卷调查结果，如泌尿生殖道疼痛指数、间质性膀胱炎症状指数/间质性膀胱炎问题指数（ICSI/ICPI）、患者健康问卷-2。评价样品的表皮内神经纤维密度。一个表皮内神经纤维密度小于第五百分位数，无论网站，表明一个积极的SPFN诊断。结果20例患者中，10例为HL IC/BPS，10例为NHL IC/BPS。HL IC/BPS组的年龄明显大于NHL IC/BPS组（63岁vs 48岁，P = 0.007）。两组之间的就业或关系状况、教育水平或合并症无显著差异。NHL IC/BPS组中60%（6/10）的患者患有SFPN，而HL IC/BPS组中40%（4/10）的患者患有SFPN。NHL和HL IC/BPS组之间的SFPN阳性（P = 0.3）或泌尿生殖系统疼痛指数、患者健康问卷-2或间质性膀胱炎症状指数/间质性膀胱炎问题指数评分无显著差异。结论与先前发表的研究相似，该队列中60%的NHL IC/BPS患者SFPN阳性，而HL IC/BPS患者仅为40%。可能需要进行更大规模的研究，以实现SVPN在IC/BPS中的全面影响。
ObjectiveThis study aimed to determine whether small fiber polyneuropathy (SFPN) diagnosis differs between Hunner lesion interstitial cystitis/bladder pain syndrome (HL IC/BPS) and non-Hunner lesion IC/BPS (NHL IC/BPS). MethodsThis was a pilot study of 20 women with IC/BPS. Results from baseline questionnaires, such as Genitourinary Pain Index, Interstitial Cystitis Symptom Index/Interstitial Cystitis Problem Index (ICSI/ICPI), Patient Health Questionnaire-2, were collected.Two punch biopsies were performed on each patient: distal leg and thigh. The samples were evaluated for intraepidermal nerve fiber density. One intraepidermal nerve fiber density less than the fifth percentile, regardless of site, indicated a positive SPFN diagnosis. ResultsTwenty patients were enrolled; 10 HL IC/BPS and 10 NHL IC/BPS. The HL IC/BPS group was found to be significantly older than the NHL IC/BPS group (63 vs 48 years, P = 0.007). No significant differences were found in employment or relationship statuses, or in levels of education or comorbidities between the 2 groups.Sixty percent (6/10) of patients had SFPN in the NHL IC/BPS group compared with 40% (4/10) in the HL IC/BPS group. No significant differences were seen in SFPN positivity (P = 0.3) or Genitourinary Pain Index, Patient Health Questionnaire-2, or Interstitial Cystitis Symptom Index/Interstitial Cystitis Problem Index scores between the NHL and HL IC/BPS groups. ConclusionsSimilar to previously published studies, 60% of NHL IC/BPS patients in this cohort were positive for SFPN compared with only 40% of the HL IC/BPS patients. Larger studies may be needed to realize the full impact of SFPN in IC/BPS.