GROWTH IN FULL-TERM SMALL-FOR-GESTATIONAL-AGE INFANTS - FROM BIRTH TO FINAL HEIGHT
GROWTH IN FULL-TERM SMALL-FOR-GESTATIONAL-AGE INFANTS - FROM BIRTH TO FINAL HEIGHT
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DOI：
10.1203/00006450-199511000-00017
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发表时间：
1995-11-01
影响因子：
3.6
通讯作者：
ALBERTSSONWIKLAND, K
中科院分区：
文献类型：
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作者：
KARLBERG, J;ALBERTSSONWIKLAND, K
宫内生长迟缓，或小于胎龄（SGA），对胎儿的发育和生存潜力有终身影响。采用瑞典哥德堡健康足月（37-43周妊娠）单胎出生队列（n = 3650）研究SGA出生儿童身材矮小的发生率和相对风险，从出生到18岁左右的最终身高。大多数婴儿，根据出生长度低于-2个标准差评分（SGA，婴儿）定义为SGA，在出生后的前6个月表现出追赶性生长，只有13.4%的SGA婴儿身高低于-2个标准差。这一比例在儿童期进一步下降，在18岁时达到7.9%。虽然大多数SGA婴儿在生命早期有追赶性生长，但那些没有追赶性生长的婴儿占矮个子青春期前儿童的21%。在18岁时，22%的“健康”足月单胎SGA(L)婴儿出生时身材矮小（86%），将在出生后6-12个月达到身高追赶，这几乎与出生体重或出生长度是否用于定义SGA无关。在剩余的非追赶型SGA婴儿中，约50%的婴儿最终身高仍然较矮，因此构成了持续身材矮小的高风险群体。
Intrauterine growth retardation, or being small for gestational age (SGA), has a life-long impact on a fetus's potential for development and survival. The incidence and relative risk of short stature in children born SGA were studied using a Swedish healthy full-term (37-43 wk of gestation) singleton birth cohort (n = 3650) from Goteborg, followed from birth to final height at about 18 y of age. Most infants, defined as SGA on the basis of a birth length less than -2 standard deviation scores (SDS) below the mean (SGA, infants), showed catch-up growth during the first 6 mo after birth, and by 1 y only 13.4% of the SGA, infants were below -2 SDS in height. This percentage decreased further during childhood to reach a value of 7.9% at 18 y of age. Although most SGA, infants have catch-up growth in early life, those who do not constitute 21% of short, prepubertal children. At 18 y of age, 22% of the total short population were short at birth (86%) of ''healthy'' full-term singleton SGA(L) infants will achieve catch-up in height during the first 6-12 mo of life, and that this is almost independent of whether birth weight or birth length is used to define SGA. Of the remaining, non-catch-up SGA infants, about 50% remain short in final height, and thus constitute a high risk group for persistent short stature.