in vitro Reactive-Accelerated-Aging (RAA) Assessment of Tissue-Engineered Electronic Nerve Interfaces (TEENI).
in vitro Reactive-Accelerated-Aging (RAA) Assessment of Tissue-Engineered Electronic Nerve Interfaces (TEENI).
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DOI：
10.1109/embc.2018.8513458
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Judy JW
中科院分区：
文献类型：
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作者：
Kuliasha CA;Judy JW
反应性加速老化（RAA）浸泡测试已被用于挑战微制造的神经接口设备对模拟最坏情况的慢性生理炎症的侵略性环境。RAA测试能够确定不同材料增加聚酰亚胺和铂-金-铂金属化薄膜界面的粘合强度的能力。发现当钛用作主要粘合促进剂时，在具有10至20 mM过氧化氢的磷酸盐缓冲盐水中在87 °C下进行的3天RAA浸泡测试导致金属-聚酰亚胺界面的粘合失效。添加氢化无定形碳化硅能够消除在7天RAA浸泡测试期间金属-聚酰亚胺界面的粘合失效的发生。然而，碳化硅层的零星破裂导致少数断裂的金属互连，这导致失效的电极。这些测试已经证明了RAA浸泡测试提供对微制造神经接口的快速体外评估的能力，从而减少了开发制造长期可靠装置的合成方法所需的时间。
A reactive-accelerated-aging (RAA) soak-test has been employed to challenge microfabricated neural interface devices against an aggressive environment that mimics worst-case chronic physiological inflammation. The RAA tests were able to determine the ability of different materials to increase the adhesive strength of the polyimide and platinum-gold-platinum metallization thin-film interface. It was found that a 3-day RAA soak-test at 87 °C in phosphate buffered saline with 10 to 20 mM hydrogen peroxide resulted in adhesive failure of the metal-polyimide interface when titanium was used as the primary adhesion promotor. The addition of hydrogenated amorphous silicon carbide was able to eliminate the onset of adhesive failure of the metal-polyimide interface during 7-day RAA soak tests. However, sporadic cracking of the silicon carbide layer resulted in a minority of broken metal interconnects that resulted in failed electrodes. These tests have demonstrated the ability of RAA soak tests to provide rapid in vitro assessment of microfabricated neural interfaces and thereby reduce the time needed to develop synthetic methods to fabricate chronically reliable devices.