RNA-binding proteins as a point of convergence of the PI3K and p38 MAPK pathways.
RNA-binding proteins as a point of convergence of the PI3K and p38 MAPK pathways.
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DOI：
10.3389/fimmu.2012.00398
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发表时间：
2012
影响因子：
7.3
通讯作者：
Turner M
中科院分区：
文献类型：
--
作者：
Venigalla RK;Turner M
了解信号转导途径介导RNA丰度变化的机制需要检查RNA从转录到降解的命运。有证据表明，RNA丰度部分受影响RNA衰变的转录后机制的调节，而这反过来又受到一些控制转录的相同信号通路的调节。此外，mRNA的翻译是受信号转导影响的关键调节步骤。这些过程在一定程度上受RNA结合蛋白（RBP）的调节，RBP与序列特异性RNA元件结合。RBPs的功能由磷酸化控制和协调。基于目前的文献，我们假设RBP可能是不同激酶如磷酸肌醇-3-激酶和丝裂原活化蛋白激酶（其调节RBP定位和功能）活性的汇聚点。
Understanding the mechanisms by which signal transduction pathways mediate changes in RNA abundance requires the examination of the fate of RNA from its transcription to its degradation. Evidence suggests that RNA abundance is partly regulated by post-transcriptional mechanisms affecting RNA decay and this in turn is modulated by some of the same signaling pathways that control transcription. Furthermore, the translation of mRNA is a key regulatory step that is influenced by signal transduction. These processes are regulated, in part, by RNA-binding proteins (RBPs) which bind to sequence-specific RNA elements. The function of RBPs is controlled and co-ordinated by phosphorylation. Based on the current literature we hypothesize that RBPs may be a point of convergence for the activity of different kinases such as phosphoinositide-3-kinase and mitogen-activated protein kinase which regulate RBP localization and function.
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影响因子：
--
作者：
Araujo PR;Yoon K;Ko D;Smith AD;Qiao M;Suresh U;Burns SC;Penalva LO
通讯作者：
Penalva LO
影响因子：
4.4
作者：
Elkon R;Zlotorynski E;Zeller KI;Agami R
通讯作者：
Agami R
影响因子：
5.3
作者：
Clement, Sandra L.;Scheckel, Claudia;Lykke-Andersen, Jens
通讯作者：
Lykke-Andersen, Jens
影响因子：
10.5
作者：
Damgaard, Christian Kroun;Lykke-Andersen, Jens
通讯作者：
Lykke-Andersen, Jens
DOI：
10.1073/pnas.0708966105
发表时间：
2008-02-05
影响因子：
11.1
作者：
Blethrow, Justin D.;Glavy, Joseph S.;Shokat, Kevan M.
通讯作者：
Shokat, Kevan M.