Molecular mechanisms of colicin evolution.
Molecular mechanisms of colicin evolution.
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DOI：
10.1093/oxfordjournals.molbev.a040081
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发表时间：
1993-11
影响因子：
10.7
通讯作者：
M. Riley
中科院分区：
文献类型：
--
作者：
M. Riley
本文就大肠杆菌毒素的起源和进化特点进行了综述。首先，16大肠杆菌素和大肠杆菌素相关蛋白的进化关系推断从氨基酸和DNA序列比较。这些比较详细的起源和多样化的大肠杆菌素集群所涉及的进化机制。这些机制包括大肠杆菌素质粒在大肠杆菌菌株之间的移动。大肠杆菌和随后的质粒共整合，大肠杆菌素和相关序列的转座和重组介导的转移，以及通过阳性选择作用使大肠杆菌素和免疫蛋白快速多样化。大肠杆菌素序列比较中包含的丰富信息使其成为探索进化变化的分子机制的理想系统。
This review explores features of the origin and evolution of colicins in Escherichia coli. First, the evolutionary relationships of 16 colicin and colicin-related proteins are inferred from amino acid and DNA sequence comparisons. These comparisons are employed to detail the evolutionary mechanisms involved in the origin and diversification of colicin clusters. Such mechanisms include movement of colicin plasmids between strains of E. coli and subsequent plasmid cointegration, transposition- and recombination-mediated transfer of colicin and related sequences, and rapid diversification of colicin and immunity proteins through the action of positive selection. The wealth of information contained in colicin sequence comparisons makes this an ideal system with which to explore molecular mechanisms of evolutionary change.