Antimicrobial residues in animal waste and water resources proximal to large-scale swine and poultry feeding operations
Antimicrobial residues in animal waste and water resources proximal to large-scale swine and poultry feeding operations
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DOI：
10.1016/s0048-9697(02)00233-4
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发表时间：
2002-11-01
影响因子：
9.8
通讯作者：
McGeehin, M
中科院分区：
文献类型：
--
作者：
Campagnolo, ER;Johnson, KR;McGeehin, M
在美国，大规模动物饲养业务（AFOs）的扩大和强化导致了对环境污染及其潜在公共卫生影响的担忧。本研究的目的是获得大规模养猪场和家禽养殖场附近动物粪便、地表水和地下水中抗菌剂残留的广泛背景数据。使用放射免疫分析和液相色谱/电喷雾电离-质谱（LC/ ESI-MS）技术测量样品中的抗菌化合物。在猪废物储存池中检测到多种类型的抗菌化合物（通常浓度> 100 mug/l）。此外，在猪和家禽养殖场附近采集的地表水和地下水样本中检测到多种抗菌化合物。这一信息表明，用作作物肥料的动物粪便可能是环境中抗菌剂残留物的来源。需要进一步研究，以确定本研究中检测到的抗菌剂水平是否对人类和/或环境生态系统有影响。放射免疫测定和LC/ESI-MS分析方法的比较证明，放射免疫测定技术仅适用于测量可能含有高水平抗菌剂的动物废物样品中的残留物。在环境样品中需要更灵敏的LC/ESI-MS技术，其中更可能存在低水平的抗菌剂残留物。(C)2002 Elsevier Science B. V.保留所有权利。
Expansion and intensification of large-scale animal feeding operations (AFOs) in the United States has resulted in concern about environmental contamination and its potential public health impacts. The objective of this investigation was to obtain background data on a broad profile of antimicrobial residues in animal wastes and surface water and groundwater proximal to large-scale swine and poultry operations. The samples were measured for antimicrobial compounds using both radioimmunoassay and liquid chromatography/electrospray ionization-mass spectrometry (LC/ ESI-MS) techniques. Multiple classes of antimicrobial compounds (commonly at concentrations of > 100 mug/l) were detected in swine waste storage lagoons. In addition, multiple classes of antimicrobial compounds were detected in surface and groundwater samples collected proximal to the swine and poultry farms. This information indicates that animal waste used as fertilizer for crops may serve as a source of antimicrobial residues for the environment. Further research is required to determine if the levels of antimicrobials detected in this study are of consequence to human and/or environmental ecosystems. A comparison of the radioimmunoassay and LC/ESI-MS analytical methods documented that radioimmunoassay techniques were only appropriate for measuring residues in animal waste samples likely to contain high levels of antimicrobials. More sensitive LC/ESI-MS techniques are required in environmental samples, where low levels of antimicrobial residues are more likely. (C) 2002 Elsevier Science B.V. All rights reserved.