Multigenomics Reveals the Causal Effect of Herpes Simplex Virus in Alzheimer's Disease: A Two-Sample Mendelian Randomization Study.
Multigenomics Reveals the Causal Effect of Herpes Simplex Virus in Alzheimer's Disease: A Two-Sample Mendelian Randomization Study.
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多基因组学揭示单纯疱疹病毒与阿尔茨海默病的因果关系：两样本孟德尔随机研究
DOI：
10.3389/fgene.2021.773725
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发表时间：
2021
影响因子：
3.7
通讯作者：
Zou X
中科院分区：
文献类型：
--
作者：
Zhang Y;Qu J;Luo L;Xu Z;Zou X
近年来，阿尔茨海默病（AD）的疱疹病毒感染假说得到了越来越多的研究者的支持。单纯疱疹病毒（HSV）是与AD相关的潜在危险因素。本研究使用双样本孟德尔随机化分析模型评估HSV与AD是否存在因果关系。与HSV-1相关的6个单核苷酸多态性（SNP）和与HSV-2相关的13个SNP被用作MR分析中的工具变量。我们使用逆方差加权（IVW）方法、MR-Egger回归（Egger）和加权中位数估计（WME）估计暴露与AD风险之间的相关性MR值。为了使结论更加稳健和可靠，进行了敏感性分析和RadialMR以评价多效性和异质性。我们发现抗HSV-1 IgG测量与AD风险无关（OR，0.96; 95%CI，0.79-1.18; p = 0.736），HSV-2也是如此（OR，1.03; 95%CI，0.94-1.12; p = 0.533）。研究结果表明，任何HSV感染似乎都不是AD干预的遗传有效靶点。
In recent years, the herpes virus infectious hypothesis for Alzheimer’s disease (AD) has gained support from an increasing number of researchers. Herpes simplex virus (HSV) is a potential risk factor associated with AD. This study assessed whether HSV has a causal relationship with AD using a two-sample Mendelian randomization analysis model. Six single-nucleotide polymorphisms (SNPs) associated with HSV-1 and thirteen SNPs associated with HSV-2 were used as instrumental variables in the MR analysis. We estimated MR values of relevance between exposure and the risk of AD using inverse-variance weighted (IVW) method, MR-Egger regression (Egger), and weighted median estimator (WME). To make the conclusion more robust and reliable, sensitivity analyses and RadialMR were performed to evaluate the pleiotropy and heterogeneity. We found that anti-HSV-1 IgG measurements were not associated with risk of AD (OR, 0.96; 95% CI, 0.79–1.18; p = 0.736), and the same was true for HSV-2 (OR, 1.03; 95% CI, 0.94–1.12; p = 0.533). The findings indicated that any HSV infection does not appear to be a genetically valid target of intervention in AD.
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影响因子：
7.7
作者：
Bowden J;Del Greco M F;Minelli C;Davey Smith G;Sheehan NA;Thompson JR
通讯作者：
Thompson JR
影响因子：
2.1
作者：
Staley JR;Burgess S
通讯作者：
Burgess S
影响因子：
12.6
作者：
Du X;Wang X;Geng M
通讯作者：
Geng M
影响因子：
3.4
作者：
Laval K;Enquist LW
通讯作者：
Enquist LW
影响因子：
30.8
作者：
Verbanck M;Chen CY;Neale B;Do R
通讯作者：
Do R