Glioblastomas with an oligodendroglial component: A pathological and molecular study
Glioblastomas with an oligodendroglial component: A pathological and molecular study
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DOI：
10.1093/jnen/60.9.863
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发表时间：
2001-09-01
影响因子：
3.2
通讯作者：
Hoang-Xuan, K
中科院分区：
文献类型：
--
作者：
He, J;Mokhtari, K;Hoang-Xuan, K
胶质母细胞瘤（GBM）被WHO分类认为是星形细胞肿瘤中最恶性的级别。然而，GBIVI的一个子集包括具有少突胶质细胞特征的可识别区域，这表明一些GBM也可能具有少突胶质细胞起源。本研究的目的是分析与少突胶质细胞成分（GBMO）相关的GBIVI的分子谱。我们分析了一系列25 GBMO。在4017 c和60%的病例中，分别观察到作为少突胶质细胞肿瘤常见标志物的I p和l9 q的杂合性缺失（洛）; 72%的肿瘤显示这些标志物中的一种或两种。除4例肿瘤（84%）外，所有肿瘤均显示出已知优先参与星形细胞肿瘤向GBM进展的改变，如EGFR扩增（44%）、P16缺失（48%）、10 q上的洛缺失（64%）。PTEN（20%）和TP 53（24%）突变。因此，GBMO显示了在“标准”GBM中发现的所有遗传畸变，其发生率相当，但与GBM不同的是在lp和19 q上具有更高的洛率。这些结果表明，GBMO可能代表了一个亚组的肿瘤少突胶质细胞来源，这是不同的“标准”GBM的turnorigenesis途径。
Glioblastoma (GBM) is considered by the WHO classification to represent the most malignant grade of the astrocytic tumors. However, a subset of GBIVI includes recognizable areas with oligodendroglial features, suggesting that some GBM may also have an oligodendroglial origin. The aim of this study was to analyze the molecular profile of GBIVI associated with an oligodendroglial component (GBMO). We analyzed a series of 25 GBMO. Loss of heterozygosity (LOH) on I p and l9q, known as common markers of oligodendroglial tumors, were observed in 4017c and 60% of cases, respectively; 72% of the tumors displayed one or both of these markers. All but 4 tumors (84%) showed alterations known to be preferentially involved in the progression of astrocytic tumors to GBM, such as EGFR amplification (44%), P16 deletion (48%), LOH on 10q (64%). PTEN (20%), and TP53 (24%) mutations. Therefore, GBMO displayed all the genetic aberrations found in "standard" GBM with a comparable incidence, but differed from GBM by having a higher rate of LOH on lp and 19q. These results suggest that GBMO might represent a subgroup of tumors of oligodendroglial origin that is distinct from the "standard" GBM in terms of turnorigenesis pathway.