Enzyme-treated Asparagus Extract (ETAS) Enhances Memory in Normal Rats and Induces Neurite-outgrowth in PC12 Cells
Enzyme-treated Asparagus Extract (ETAS) Enhances Memory in Normal Rats and Induces Neurite-outgrowth in PC12 Cells
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DOI：
10.1177/1934578x1701201027
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发表时间：
2017-10-01
影响因子：
1.8
通讯作者：
Imai, Hideki
中科院分区：
文献类型：
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作者：
Koda, Tomoko;Takanari, Jun;Imai, Hideki
酶处理的芦笋提取物（ETAS）含有多种植物化学物质。有报道称，ETAS可以保护SAMP8小鼠的早期认知障碍和A β诱导的PC12细胞活力降低。此外，ETAS对健康人有几种作用。本研究旨在探讨ETAS对大鼠正常记忆功能及PC12细胞神经突生长的影响。在体外研究中，ETAS显著加速了神经突的生长。综上所述，ETAS对正常大鼠早期记忆功能有影响。这种作用的基础可能是在神经元中诱导神经突生长。
Enzyme-treated asparagus extract (ETAS) contains various phytochemicals. It has been reported that ETAS protected early cognitive impairment of SAMP8 mice and A beta-induced reduction of PC12 cell viability. In addition, ETAS had several functions on healthy people. The purpose of the present study was to investigate the effects of ETAS on normal memory function of rats and neurite-outgrowth of PC12 cells. ETAS significantly accelerated learning acquisition in in vivo and neurite-outgrowth in in vitro study. In conclusion, ETAS affected on memory function in early stage in normal rats. The basis of this effect may induce neurite-outgrowth in neurons.