Hypertranscription in Development, Stem Cells, and Regeneration.
Hypertranscription in Development, Stem Cells, and Regeneration.
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DOI：
10.1016/j.devcel.2016.11.010
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发表时间：
2017-01-09
影响因子：
11.8
通讯作者：
Ramalho-Santos M
中科院分区：
文献类型：
--
作者：
Percharde M;Bulut-Karslioglu A;Ramalho-Santos M
细胞可以在特定的转换过程中全面上调其转录组，这种现象称为超转录。超转录的证据可以追溯到70多年前，但直到最近，它在基因组学时代一直被忽视。我们讨论的数据支持的概念，超转录是一个统一的主题在胚胎发育，干细胞生物学，再生和细胞竞争。本文综述了超转录的研究历史、分析方法、机制和生物学意义。
Cells can globally up-regulate their transcriptome during specific transitions, a phenomenon called hypertranscription. Evidence for hypertranscription dates back over 70 years, but it has gone largely ignored in the genomics era until recently. We discuss data supporting the notion that hypertranscription is a unifying theme in embryonic development, stem cell biology, regeneration and cell competition. We review the history, methods for analysis, underlying mechanisms and biological significance of hypertranscription.