Lipid alterations in the earliest clinically recognizable stage of Alzheimer's disease: Implication of the role of lipids in the pathogenesis of Alzheimer's disease
Lipid alterations in the earliest clinically recognizable stage of Alzheimer's disease: Implication of the role of lipids in the pathogenesis of Alzheimer's disease
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DOI：
10.2174/1567205052772786
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发表时间：
2005-01-05
影响因子：
2.1
通讯作者：
Han, Xianlin
中科院分区：
文献类型：
--
作者：
Han, Xianlin
脂质在细胞内稳态中具有许多重要且独特的功能，例如形成将细胞内和细胞外区间分隔开的不可渗透的屏障，为膜相关蛋白的适当相互作用提供基质，以及作为具有生物活性的第二信使的储存库。因此，细胞脂质的改变可能导致细胞功能异常。本综述总结了对阿尔茨海默病（AD）中脂质改变的研究结果。除了胆固醇对AD的影响外，缩醛磷脂和脑硫脂的大量减少以及神经酰胺的急剧增加在AD临床上可识别的最早阶段就有特异性表现。还讨论了这些变化背后的潜在机制以及这些变化在神经元功能和AD发展中的潜在后果。总之，本综述将概述阿尔茨海默病中的脂质改变以及这些脂质改变与AD发病机制发展的关系。
Lipids have many important yet distinct functions in cellular homeostasis such as forming an impermeable barrier separating intracellular and extracellular compartments, providing a matrix for the appropriate interactions of membrane-associated proteins, and serving as storage reservoirs for biologically active second messengers. Alterations in cellular lipids may therefore result in abnormal cellular functions. This review summarizes the results from the examination of lipid alterations in Alzheimer's disease (AD). In addition to the effects of cholesterol on AD, substantial depletions of plasmalogen and sulfatide as well as dramatic increases in ceramide are specifically manifested at the earliest clinically recognizable stage of AD. The potential mechanism(s) underlying these changes and the potential consequences of these changes in neuronal function and in AD development are also discussed. Collectively, this review will provide an overview of the lipid alterations in Alzheimer's disease and the relationship of these lipid alterations with the development of AD pathogenesis.