Mouse models for the genetic study of tuberculosis susceptibility.
Mouse models for the genetic study of tuberculosis susceptibility.
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DOI：
10.1093/bfgp/4.3.277
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发表时间：
2005-11
期刊：
影响因子：
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通讯作者：
Tania Di Pietrantonio;E. Schurr
中科院分区：
文献类型：
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作者：
Tania Di Pietrantonio;E. Schurr
结核病主要由致病菌结核分枝杆菌引起，尽管已确定使用卡介苗（BCG）疫苗、多种药物治疗和存在全球结核病控制规划，但结核病仍然是一个不可估量的公共卫生问题。统计数据显示，近20亿人（约占世界人口的三分之一）感染了结核分枝杆菌。由于未知的原因，感染结核分枝杆菌的人中只有大约10%会发展成结核病，每年造成900万新病例和200万人死亡。更好地了解宿主-分枝杆菌-环境的相互作用对于开发更好的抗结核疫苗和治疗至关重要。这篇综述将讨论如何更清晰地了解这种相互作用，并在小鼠模型中采用新的基因组策略。
Tuberculosis, mainly caused by the pathogenic bacterium Mycobacterium tuberculosis, remains an inestimable public health problem, despite the established use of the Bacillus Calmette-Guerin (BCG) vaccine, multidrug therapy and the existence of global tuberculosis control programmes. Statistics show that nearly 2 billion people (approximately one-third of the world's population) are infected with M. tuberculosis. For unknown reasons, only about 10 per cent of those infected by M. tuberculosis will develop tuberculosis, resulting in 9 million new cases yearly and 2 million deaths. A better understanding of the host--mycobacterial--environmental interplay is central to developing better antituberculosis vaccines and treatments. This review will discuss how a clearer idea of this interplay is emerging with new genomic strategies in mouse models.