MECHANICAL-PROPERTIES OF XENOGENEIC SMALL-INTESTINAL SUBMUCOSA WHEN USED AS AN AORTIC GRAFT IN THE DOG
MECHANICAL-PROPERTIES OF XENOGENEIC SMALL-INTESTINAL SUBMUCOSA WHEN USED AS AN AORTIC GRAFT IN THE DOG
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DOI：
10.1002/jbm.820290714
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发表时间：
1995-07-01
期刊：
影响因子：
--
通讯作者：
MORFF, RJ
中科院分区：
文献类型：
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作者：
HILES, MC;BADYLAK, SF;MORFF, RJ
小肠粘膜下层（SIS）作为血管移植物在体内可诱导组织重塑。本研究调查的物理和机械性能的重建主动脉移植物来自异种SIS材料。在杂种犬中植入8个肾下主动脉移植物。移植物在1个月或2个月时取出，并测试顺应性和环力学性能。移植物内的形态学变化也进行了表征。重塑过程产生的移植物结构明显强于正常动脉（P = .012）和原始SIS移植物（P = .0001），这些结构的顺应性是正常动脉的三分之一，与原始SIS移植物相似。重塑移植物的厚度是植入SIS的10倍以上。重塑组织的免疫组织化学分析表明，SIS材料随着时间的推移而降解和再吸收。重塑过程将一种在物理和机械上与正常主动脉完全不同的材料转化为具有在该哺乳动物动脉系统中发挥功能所需的物理和机械特性的血管。(C)1995年，John Wiley and Sons，Inc.
Small-intestinal submucosa (SIS) has been shown to induce tissue remodeling in vivo when used as a vascular graft. The present study investigated the physical and mechanical properties of remodeled aortic grafts derived from xenogeneic SIS material. Eight infrarenal aortic grafts were implanted in mongrel dogs. The grafts were explanted at 1 or 2 months and tested for compliance and hoop mechanical properties. The morphologic changes within the grafts were also characterized. The remodeling process produced graft structures which were significantly stronger than both the normal artery (P = .012) and the original SIS graft (P = .0001), and the compliance of these structures was one third that of normal artery and similar to the original SIS grafts. The remodeled grafts were >10 times the thickness of the implanted SIS. Immunohistochemical analysis of remodeled tissues suggest that the SIS material was degraded and resorbed over time. The remodeling process transformed a material which was physically and mechanically quite different from normal aorta into a blood conduit which had the physical and mechanical properties needed to function in this mammalian arterial system. (C) 1995 John Wiley and Sons, Inc.