Dose-rate effects in normal and malignant cells of human origin.
Dose-rate effects in normal and malignant cells of human origin.
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DOI：
10.1259/0007-1285-60-714-573
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发表时间：
1987-06
期刊：
影响因子：
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通讯作者：
M. Marchese;M. Zaider;E. Hall
中科院分区：
文献类型：
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作者：
M. Marchese;M. Zaider;E. Hall
在平台期，在急性（81戈伊/h）或长期（0.1-0.7戈伊/h）暴露条件下对来自正常组织和恶性肿瘤的人细胞系进行辐照，以确定初始存活曲线斜率，评估亚致死损伤修复（SLDR）能力，并确定在一定剂量率范围内SLDR导致的存活差异。在2戈伊剂量下，未发现肿瘤类型的临床耐药与初始斜率或存活率之间存在相关性。通过比较急性和连续照射的存活曲线来评估亚致死损伤修复。所有细胞系均显示出显著的SLDR，临床上更具耐药性的肿瘤类型显示出最佳的恢复率。存活数据还表明，在0.1-0.7戈伊/h范围内，细胞杀伤几乎没有差异。使用修改后的线性二次模型与SLDR的规定，它被发现，对于这些细胞系的修复半衰期小于1小时，在剂量率低于1戈伊/h的亚致死损伤的恢复量没有显着变化。
Human cell lines derived from normal tissue and malignant tumours were irradiated in plateau phase under acute (81 Gy/h) or protracted (0.1-0.7 Gy/h) exposure to determine initial survival curve slopes, assess sublethal damage repair (SLDR) capability, and establish differences in survival due to SLDR over a range of dose rates. No correlation was found between clinical resistance of the tumor types and initial slope or survival at 2 Gy. Sublethal damage repair was assessed by comparing survival curves for acute and continuous irradiation. All cell lines showed significant SLDR, with the more clinically resistant tumour types demonstrating the best recovery rates. The survival data also demonstrated little difference in cell killing over the 0.1-0.7 Gy/h range. Using a modified linear-quadratic model with provisions for SLDR, it was found that for these cell lines the repair half-time was less than 1 h, with no significant change in the amount of recovery from sublethal damage at dose rates below 1 Gy/h.