Asymmetric organocatalytic oxy-Michael addition of alcohols to α,β-unsaturated aldehydes
Asymmetric organocatalytic oxy-Michael addition of alcohols to α,β-unsaturated aldehydes
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DOI：
10.1016/j.tet.2007.03.179
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发表时间：
2007-08-27
期刊：
影响因子：
2.1
通讯作者：
Maruoka, Keiji
中科院分区：
文献类型：
--
作者：
Kano, Taichi;Tanaka, Youhei;Maruoka, Keiji
发现联苯二胺基催化剂 3 可以有效促进醇与 α,β-不饱和醛的 1,4-加成，而不会形成缩醛。通过设计新型轴向手性有机催化剂 (R)-10c，也实现了该反应的不对称变体。 (c) 2007 Elsevier Ltd. 保留所有权利。
A 1,4-addition of alcohols to alpha,beta-unsaturated aldehydes was found to be efficiently promoted by biphenyldiamine-based catalyst 3 without formation of the acetals. An asymmetric variant of this reaction has also been performed by designing a novel axially chiral organo-catalyst (R)-10c. (c) 2007 Elsevier Ltd. All rights reserved.