Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial
Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial
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DOI：
10.1002/jsfa.10096
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发表时间：
2019-11-21
影响因子：
4.1
通讯作者：
Esmaeilinezhad, Zahra
中科院分区：
文献类型：
--
作者：
Boldaji, Reza Barati;Akhlaghi, Masoumeh;Esmaeilinezhad, Zahra
研究背景补骨脂具有抗氧化、心脏保护和抗炎作用。我们设计了一项交叉研究，旨在确定石榴汁（PJ）的消费是否改善血液透析患者的血脂和氧化和炎症生物标志物。将41例血液透析患者随机分为两组：PJ治疗组在透析后立即接受100 mL天然PJ，每周3次，对照组接受常规护理。8周后，建立4周的洗脱期，然后交换各组的角色。在每个序列之前和之后测量血脂、血压以及氧化和炎症生物标志物。结果根据意向处理分析结果，PJ组甘油三酯降低，对照组甘油三酯升高。相反，高密度脂蛋白胆固醇在PJ中增加，而在对照组中降低。两种情况下总胆固醇和低密度脂蛋白胆固醇均无显著变化。收缩压和舒张压在PJ状态下显著降低。总抗氧化能力在PJ条件下增加（P < 0.001），而对照组降低（P < 0.001）。PJ组MDA、IL-6水平降低（P < 0.001），对照组升高（P < 0.001）。
BACKGROUND Pomegranate has antioxidant, cardioprotective and anti-inflammatory properties. We designed a crossover study aimed at determining if consumption of pomegranate juice (PJ) improves lipid profile and oxidative and inflammatory biomarkers of hemodialysis patients. Forty-one hemodialysis patients were randomly assigned to one of two groups: PJ-treated group receiving 100 mL of natural PJ immediately after their dialysis session three times a week and the control group receiving the usual care. After 8 weeks, a 4-week washout period was established and then the role of the groups was exchanged. Lipid profile, blood pressure and oxidative and inflammatory biomarkers were measured before and after each sequence. RESULTS Based on the results of intention-to-treat analysis, triglycerides were decreased in PJ condition and increased in the controls. Conversely, high-density lipoprotein cholesterol was increased in PJ and decreased in the control group. Total and low-density lipoprotein cholesterol did not significantly change in either condition. Systolic and diastolic blood pressure significantly decreased in PJ condition. Total antioxidant capacity increased in PJ condition (P < 0.001) and decreased in the controls (P < 0.001). Conversely, malondialdehyde and interleukin-6 decreased in PJ (P < 0.001) and increased in the control group (P