Vaccination against the 2009 pandemic influenza A (H1N1) among healthcare workers in the major teaching hospital of Sicily (Italy)
Vaccination against the 2009 pandemic influenza A (H1N1) among healthcare workers in the major teaching hospital of Sicily (Italy)
复制标题
DOI：
10.1016/j.vaccine.2010.12.041
复制
发表时间：
2011-02-04
期刊：
影响因子：
5.5
通讯作者：
Firenze, Alberto
中科院分区：
文献类型：
--
作者：
Amodio, Emanuele;Anastasi, Giovanna;Firenze, Alberto
该研究的目的是调查卫生工作者（HCW）接受疫苗接种的因素以及与大流行性流感疫苗接种相关的不良反应率。该研究于2009年11月至2010年2月在西西里的主要教学医院对2267名HCW进行。共有407名（18%）医务工作者接种了2009年甲型H1N1流感疫苗。逻辑回归分析表明，女性未接种大流行性流感疫苗的风险增加（OR = 1.6; 95% CI = 1.3-2.1）与男性相比，在护士/技术人员/行政人员中（OR = 1.7; 95% CI = 1.3-2.2），与医生/生物学家相比，以及2008-2009年未接种季节性流感疫苗的医护人员（OR = 4.9; 95% CI = 3.7-6.5）。总体而言，在观察期内，分发给接种疫苗的HCW的407份问卷中有302份（74.2%）被退回。152名工人（50.3%）经历了至少一次不良反应（30.1%，局部反应; 6.6%全身反应和13.6%两者）。最常见的副作用是注射部位疼痛（43.4%）。302名HCW中有12名（3.9%）表示在随访期间发生了流感样疾病。使用含佐剂的疫苗预防甲型H1N1流感似乎是一种有效和安全的预防策略，显示局部和全身不良反应的发生率与接种无佐剂的季节性流感疫苗后观察到的发生率没有很大差异。尽管有这一发现，医务工作者的疫苗接种覆盖率仍然很低，这表明有必要针对覆盖率较低的群体开展教育运动。(C)2010爱思唯尔有限公司保留所有权利。
The aim of the study was to investigate factors involved in vaccination acceptance among healthcare workers (HCWs) and adverse reactions rates associated with pandemic influenza vaccination. The study was carried out in the major teaching hospital of Sicily from November 2009 to February 2010 on 2267 HCWs. A total of 407 (18%) HCWs were vaccinated against the 2009 pandemic influenza A (H1N1). A logistic regression analysis indicates an increased risk of non-vaccination against pandemic influenza in females (OR = 1.6; 95% CI = 1.3-2.1) compared to males, in nurses/technicians/administrative workers (OR = 1.7; 95% CI = 1.3-2.2) compared to doctors/biologists, and in HCWs who were non-vaccinated against seasonal influenza in 2008-2009 (OR = 4.9; 95% CI = 3.7-6.5) compared to vaccinated HCWs. Overall, 302 (74.2%) out of 407 questionnaires distributed to vaccinated HCWs were returned within the observation period. One hundred fifty-two workers (50.3%) experienced at least one adverse reaction (30.1%, local reactions; 6.6% systemic reactions and 13.6% both of them). The most frequent side effect of vaccination was pain at the injection site (43.4%). Twelve (3.9%) out of 302 HCWs stated they experienced influenza-like illness episodes during the follow-up period. The use of an adjuvanted vaccine against pandemic influenza A (H1N1) appears to be an effective and safe preventive strategy, showing a prevalence of both local and systemic adverse reactions not very different from that seen after vaccination with non-adjuvanted seasonal influenza vaccine. Despite this finding, vaccination coverage among HCWs remains very low, suggesting the need to implement educational campaigns directed to groups with lower coverage rates. (C) 2010 Elsevier Ltd. All rights reserved.