Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan. Japan Diabetic Nephropathy Cohort Study : study design, methods, and implementation
Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan. Japan Diabetic Nephropathy Cohort Study : study design, methods, and implementation
复制标题
日本厚生劳动省糖尿病肾病研究组。
DOI：
10.1007/s10157-013-0778-8
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发表时间：
2013
期刊：
影响因子：
2.3
通讯作者：
Wada T
中科院分区：
文献类型：
--
作者：
Furuichi K1;Shimizu M;Toyama T;Koya D;Koshino Y;Abe H;Mori K;Satoh H;Imanishi M;Iwano M;Yamauchi H;Kusano E;Fujimoto S;Suzuki Y;Okuda S;Kitagawa K;Iwata Y;Kaneko S;Nishi S;Yokoyama H;Ueda Y;Haneda M;Makino H;Wada T
背景糖尿病肾病是终末期肾脏疾病，对公众健康和社会经济有相当大的影响。然而，日本很少有糖尿病肾病的国家登记。这项前瞻性队列研究的目的是获得临床数据和尿液样本修订糖尿病肾病的临床分期，并开发新的早期糖尿病肾病的诊断标志物。MethodsThe日本肾脏病学会建立了一个全国性的，基于网络的，前瞻性的注册系统。在该系统中，有两个基本登记处：日本肾活检登记处（JRBR）和日本肾脏疾病登记处（JKDR）。除了这两个基本的登记处，我们建立了一个新的前瞻性登记系统;日本糖尿病肾病队列研究（JDNCS），收集的物理和实验室data.ResultsWe分析了321名参与者（106名女性，215名男性，平均年龄65岁）在JDNCS的数据。收缩压和舒张压分别为130.1和72.3 mmHg。估计肾小球滤过率（eGFR）中位数为33.3 ml/min/1.73 m2。蛋白尿为1.8 g/gCr，血清白蛋白水平为3.6 g/dl。大多数JDNCS患者表现为eGFR保留和低蛋白尿或低eGFR和晚期蛋白尿。在JRBR和JKDR登记研究中，分别有484名和125名参与者入选为糖尿病患者。与JRBR和JKDR登记处相比，JDNCS的特征是糖尿病患者表现为低蛋白尿，eGFR保持适度。结论日本很少有国家糖尿病肾病登记处来评估预后。JDNCS的未来分析将为日本2型糖尿病患者的流行病学以及肾脏和心血管结局提供临床见解。
BackgroundDiabetic nephropathy, leading to end-stage renal disease, has a considerable impact on public health and the social economy. However, there are few national registries of diabetic nephropathy in Japan. The aims of this prospective cohort study are to obtain clinical data and urine samples for revising the clinical staging of diabetic nephropathy, and developing new diagnostic markers for early diabetic nephropathy.MethodsThe Japanese Society of Nephrology established a nationwide, web-based, and prospective registry system. On the system, there are two basic registries; the Japan Renal Biopsy Registry (JRBR), and the Japan Kidney Disease Registry (JKDR). In addition to the two basic registries, we established a new prospective registry to the system; the Japan Diabetic Nephropathy Cohort Study (JDNCS), which collected physical and laboratory data.ResultsWe analyzed the data of 321 participants (106 female, 215 male; average age 65 years) in the JDNCS. Systolic and diastolic blood pressure was 130.1 and 72.3 mmHg, respectively. Median estimated glomerular filtration rate (eGFR) was 33.3 ml/min/1.73 m2. Proteinuria was 1.8 g/gCr, and serum levels of albumin were 3.6 g/dl. The majority of the JDNCS patients presented with preserved eGFR and low albuminuria or low eGFR and advanced proteinuria. In the JRBR and JKDR registries, 484 and 125 participants, respectively, were enrolled as having diabetes mellitus. In comparison with the JRBR and JKDR registries, the JDNCS was characterized by diabetic patients presenting with low proteinuria with moderately preserved eGFR.ConclusionsThere are few national registries of diabetic nephropathy to evaluate prognosis in Japan. Future analysis of the JDNCS will provide clinical insights into the epidemiology and renal and cardiovascular outcomes of type 2 diabetic patients in Japan.