An overview of developmental genetics in mammals.
An overview of developmental genetics in mammals.
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哺乳动物发育遗传学概述。
DOI：
10.1016/s0959-437x(05)80164-9
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发表时间：
1992
影响因子：
4
通讯作者：
Gluecksohn-Waelsch,S
中科院分区：
文献类型：
--
作者：
Gluecksohn-Waelsch,S
在过去一年中，哺乳动物发育遗传学的出版物反映了重点从表型水平转移到基因表达的初级水平和基因产物的性质。因此，已经鉴定了相当数量的调控基因和特定基因序列的发育作用。过去分析的几种突变的细胞类型特异性效应与对生长因子和信号转导途径的影响相关。特定的基因序列，如那些含有同源框结构域和配对框序列最近被牵连在控制模式的形成和位置信息。
Publications in mammalian developmental genetics during the past year reflect a shift of emphasis from the phenotypic level to the primary level of gene expression and the nature of the gene product. A result of this, the developmental role of a considerable number of regulatory genes and specific gene sequences have been identified. The cell type-specific effects of several mutations analyzed in the past have been correlated with effects on growth factors and signal transduction pathways. Specific gene sequences such as those containing the homeobox domains and paired-box sequences have recently been implicated in the control of pattern formation and positional information.