Protein backbone engineering as a strategy to advance foldamers toward the frontier of protein-like tertiary structure.
Protein backbone engineering as a strategy to advance foldamers toward the frontier of protein-like tertiary structure.
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蛋白质主链工程作为一种将折叠分子推向类蛋白质三级结构前沿的策略。
DOI：
10.1039/c4ob01769b
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发表时间：
2014
影响因子：
3.2
通讯作者：
Horne,WSeth
中科院分区：
文献类型：
--
作者：
Reinert,ZacharyE;Horne,WSeth
各种非生物结构基序已被并入天然蛋白质序列的主链中。在平行的工作中，已经开发了以定义的方式折叠的从头设计的多种非天然寡聚体（称为“折叠体”）。在这篇透视文章中，我们调查了蛋白质骨架工程的基础研究，重点是在复杂的三级折叠的背景下进行的改变。我们继续总结最近的工作，说明这些方法提供了一个一般的框架，构建蛋白质三级结构的foldamer模拟的潜在承诺。
A variety of non-biological structural motifs have been incorporated into the backbone of natural protein sequences. In parallel work, diverse unnatural oligomers of de novo design (termed “foldamers”) have been developed that fold in defined ways. In this Perspective article, we survey foundational studies on protein backbone engineering, with a focus on alterations made in the context of complex tertiary folds. We go on to summarize recent work illustrating the potential promise of these methods to provide a general framework for the construction of foldamer mimics of protein tertiary structures.